Biofilm-Producing Candida Species Causing Oropharyngeal Candidiasis in HIV Patients Attending Sukraraj Tropical and Infectious Diseases Hospital in Kathmandu, Nepal

Oropharyngeal candidiasis are the commonest fungal infections among HIV-positive patients. The main objective of this study was to explore biofilm-producing species causing oropharyngeal infections among HIV patients attending Sukraraj Tropical and Infectious Diseases Hospital (STIDH) in Kathmandu,...

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Bibliographic Details
Published in:HIV/AIDS (Auckland) 2020-01, Vol.12, p.211-220
Main Authors: Lamichhane, Keshav, Adhikari, Nabaraj, Bastola, Anup, Devkota, Lina, Bhandari, Parmananda, Dhungel, Binod, Thapa Shrestha, Upendra, Adhikari, Bipin, Banjara, Megha Raj, Rijal, Komal Raj, Ghimire, Prakash
Format: Article
Language:English
Subjects:
Antibacterial agents
antifungal susceptibility test
biofilm
Brazil
candida albicans
Candidiasis
Diseases
Health aspects
HIV
HIV patients
India
Ketoconazole
Nepal
Nigeria
oral candidiasis
Original Research
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Summary:Oropharyngeal candidiasis are the commonest fungal infections among HIV-positive patients. The main objective of this study was to explore biofilm-producing species causing oropharyngeal infections among HIV patients attending Sukraraj Tropical and Infectious Diseases Hospital (STIDH) in Kathmandu, Nepal. Oropharyngeal swabs were collected from the HIV-positive patients between July and December 2019. A total of 174 oropharyngeal swabs were cultured on Sabouraud Dextrose Agar (SDA). All samples were inoculated on SDA slants supplemented with chloramphenicol and underwent incubation at 37°C for 24-48 hours. Any visible growth reported was processed for the identification of the species. species were differentiated based on the growth and colour of the isolates on CHROM agar candida. Biofilm production in species was determined by the microtiter plate method (MPM). Antifungal susceptibility testing was performed using the disc diffusion method. Among 174 oropharyngeal samples, 23.6% (n=41/174) of them had oropharyngeal infections and 36.6% of the oropharyngeal infections (15/41) had CD4 T-lymphocytes count below 200 cells/mm who were also active tobacco users (p
ISSN:1179-1373
1179-1373
DOI:10.2147/HIV.S255698