Gut microbiome, metabolome, and allergic diseases

The number of patients with allergic and inflammatory disorders has been increasing during the past several decades. Accumulating evidence has refined our understanding of the relationship between allergic diseases and the gut microbiome. In addition, the gut microbiome is now known to produce both...

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Bibliographic Details
Published in:Allergology International 2017-10, Vol.66 (4), p.523-528
Main Authors: Hirata, So-ichiro, Kunisawa, Jun
Format: Article
Language:English
Subjects:
Amino acid
Amino Acids - metabolism
Animals
Bacteria - metabolism
Disease Susceptibility
Fatty Acids - metabolism
Gastrointestinal Microbiome
Humans
Hypersensitivity - etiology
Hypersensitivity - metabolism
Immunomodulation
Lipids
Metabolome
Microbiome
Short-chain fatty acid
Vitamin
Vitamins - metabolism
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Summary:The number of patients with allergic and inflammatory disorders has been increasing during the past several decades. Accumulating evidence has refined our understanding of the relationship between allergic diseases and the gut microbiome. In addition, the gut microbiome is now known to produce both useful and harmful metabolites from dietary materials. These metabolites and bacterial components help to regulate host immune responses and potentially affect the development of allergic diseases. Here, we describe recent findings regarding the immunologic crosstalk between commensal bacteria and dietary components in the regulation of host immunity and the influence of this relationship on the development of allergic diseases.
ISSN:1323-8930
1440-1592
DOI:10.1016/j.alit.2017.06.008