Changes in the prevalence of hyperuricemia in clients of health examination in Eastern China, 2009 to 2019

• Published in: BMC endocrine disorders 2022-08, Vol.22 (1), p.1-202, Article 202
• Main Authors: She, Dunmin, Wang, Yongliang, Liu, Jing, Luo, Na, Feng, Shangyong, Li, Ying, Xu, Jin, Xie, Shichun, Zhu, Yan, Xue, Ying, Zhang, Zhenwen
• Format: Article
• Language: English
• Subjects: Age; Age groups; Blood pressure; Body mass index; Cholesterol; Correlation analysis; Creatinine; Females; High density lipoprotein; Hyperuricemia; Industrialized nations; Low density lipoprotein; Males; Metabolism; Middle age; Prevalence; Risk factors; Serum uric acid level; Sex differences; Statistical analysis; Uric acid; Womens health; Young adults
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-022-01118-z

Background With the continuous improvement of people's living standards, the incidence of hyperuricemia (HUA) is increasing globally. The prevalence of HUA ranged in terms of region, race, and age. This study aims to investigate the changes in the prevalence of HUA in clients of health examination in Eastern China between 2009 and 2019. Methods Chinese men and women aged 20–79 years (n = 4847 in the 2009 group and n = 12,188 in 2019 group) who had received health examinations were enrolled. Serum uric acid (UA) levels and biochemical parameters, including fasting blood-glucose (FBG), triglyceride (TG), total cholesterol (CHOL), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr) and blood urea nitrogen (BUN) were evaluated. The prevalence of HUA in different age groups were measured, and the correlation of biochemical parameters with HUA were analyzed. Results The prevalence of HUA was 18.7% in the 2019 group, which was significantly higher than that in 2009 (11.1%). In females, the prevalence of HUA was significantly higher in 2019 than 2009 for age groups of 20–29 and 30–39 years. In male population, 2019 participants had significantly higher age-specific prevalence for all age groups than 2009 participants. Young men aged 20–29 years became the main population of HUA in the 2019 participants, whereas middle-aged men aged 40–49 years had the highest prevalence of HUA in the 2009 participants. The prevalence rates of HUA in all BMI groups in 2019 participants were significantly higher than those in 2009 participants. Spearmen’s correlation analysis and Logistic regression analysis indicated that BMI was positively correlated with HUA. The receiver-operating characteristic curve (ROC) analysis showed BMI > 24.48 kg/m2 and BMI > 23.84 kg/m2 displayed good capacities to discriminate the population with HUA from those without HUA in 2009 and 2019 participants, respectively. Conclusions In recent 10 years, the prevalence of HUA was increased rapidly in Chinese adults, especially in males. In 2019, the young male group (20–29 years old) replaced the middle-aged male group (40–49 years old) in 2009 as the leading age group for male HUA. BMI was positively correlated with HUA, and might be a potential risk factors to predict HUA.