FGFR1 and WT1 are markers of human prostate cancer progression

Androgen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men. We used DNA microarrays to identify genes related to the transition between androgen-dependent and androgen-independent stages in the LuCaP 23.1 xenograft model of prostate adenocarcinoma. The...

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Bibliographic Details
Published in:BMC cancer 2006-11, Vol.6 (1), p.272-272, Article 272
Main Authors: Devilard, Elizabeth, Bladou, Franck, Ramuz, Olivier, Karsenty, Gilles, Dalès, Jean-Philippe, Gravis, Gwenaëlle, Nguyen, Catherine, Bertucci, François, Xerri, Luc, Birnbaum, Daniel
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Animals
Antigens, Neoplasm - metabolism
Biochemistry, Molecular Biology
Biomarkers, Tumor - isolation & purification
Biomarkers, Tumor - metabolism
Disease Progression
Fetal Proteins - metabolism
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Life Sciences
Male
MART-1 Antigen
Mice
Microtubule-Associated Proteins - metabolism
Middle Aged
Models, Biological
Neoplasm Proteins - metabolism
Neoplasm Staging - methods
Nuclear Proteins - metabolism
Oligonucleotide Array Sequence Analysis
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Receptor, Fibroblast Growth Factor, Type 1 - metabolism
WT1 Proteins - metabolism
Xenograft Model Antitumor Assays
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Summary:Androgen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men. We used DNA microarrays to identify genes related to the transition between androgen-dependent and androgen-independent stages in the LuCaP 23.1 xenograft model of prostate adenocarcinoma. The expression of the proteins encoded by these genes was then assessed by immunohistochemistry on tissue microarrays (TMA) including human prostate carcinoma samples issued from 85 patients who had undergone radical prostatectomy. FGFR1, TACC1 and WT1 gene expression levels were associated with the androgen-independent stage in xenografts and human prostate carcinoma samples. MART1 protein expression was correlated with pT2 tumor stages. Our results suggest that each of these four genes may play a role, or at least reflect a stage of prostate carcinoma growth/development/progression.
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-6-272