Antitumoral materials with regenerative function obtained using a layer-by-layer technique

• Published in: Drug design, development and therapy development and therapy, 2015-01, Vol.9 (default), p.1269-1279
• Main Authors: Ficai, Denisa, Sonmez, Maria, Albu, Madalina Georgiana, Mihaiescu, Dan Eduard, Ficai, Anton, Bleotu, Coralia
• Format: Article
• Language: English
• Subjects: Anticancer properties; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biomedical materials; Bone cancer; Bone healing; Bone regeneration; Bone Regeneration - drug effects; Cancer therapies; Care and treatment; Cell Cycle - drug effects; Cell Death - drug effects; Chemotherapy; Chlorine; Cisplatin; Cisplatin - administration & dosage; Cisplatin - chemistry; Cisplatin - pharmacology; Collagen; Collagen - administration & dosage; Collagen - chemistry; Collagen - pharmacology; Composite materials; Cytostatic agents; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; Drug Delivery Systems; Durapatite - administration & dosage; Durapatite - chemistry; Durapatite - pharmacology; Electromagnetic fields; Electromagnetism; Ferrosoferric Oxide - administration & dosage; Ferrosoferric Oxide - chemistry; Ferrosoferric Oxide - pharmacology; Fever; HeLa Cells; Humans; Hydroxyapatite; Hyperthermia; Identification and classification; Innovations; Iron oxides; Magnetite; Melanoma; Original Research; R&D; Research & development; Skin cancer; Structure-Activity Relationship; Surgery; Surgical implants; Toxicity; Wound Healing - drug effects
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S62805

A layer-by layer technique was successfully used to obtain collagen/hydroxyapatite-magnetite-cisplatin (COLL/HAn-Fe3O4-CisPt, n=1-7) composite materials with a variable content of hydroxyapatite intended for use in the treatment of bone cancer. The main advantages of this system are the possibility of controlling the rate of delivery of cytostatic agents, the presence of collagen and hydroxyapatite to ensure more rapid healing of the injured bone tissue, and the potential for magnetite to be a passive antitumoral component that can be activated when an appropriate external electromagnetic field is applied. In vitro cytotoxicity assays performed on the COLL/HAn-Fe3O4-CisPt materials obtained using a layer-by layer method confirmed their antitumoral activity. Samples with a higher content of hydroxyapatite had more antitumoral activity because of their better absorption of cisplatin and consequently a higher amount of cisplatin being present in the matrices.