Antitumoral materials with regenerative function obtained using a layer-by-layer technique

A layer-by layer technique was successfully used to obtain collagen/hydroxyapatite-magnetite-cisplatin (COLL/HAn-Fe3O4-CisPt, n=1-7) composite materials with a variable content of hydroxyapatite intended for use in the treatment of bone cancer. The main advantages of this system are the possibility...

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Published in:Drug design, development and therapy development and therapy, 2015-01, Vol.9 (default), p.1269-1279
Main Authors: Ficai, Denisa, Sonmez, Maria, Albu, Madalina Georgiana, Mihaiescu, Dan Eduard, Ficai, Anton, Bleotu, Coralia
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biomedical materials
Bone cancer
Bone healing
Bone regeneration
Bone Regeneration - drug effects
Cancer therapies
Care and treatment
Cell Cycle - drug effects
Cell Death - drug effects
Chemotherapy
Chlorine
Cisplatin
Cisplatin - administration & dosage
Cisplatin - chemistry
Cisplatin - pharmacology
Collagen
Collagen - administration & dosage
Collagen - chemistry
Collagen - pharmacology
Composite materials
Cytostatic agents
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
Drug Delivery Systems
Durapatite - administration & dosage
Durapatite - chemistry
Durapatite - pharmacology
Electromagnetic fields
Electromagnetism
Ferrosoferric Oxide - administration & dosage
Ferrosoferric Oxide - chemistry
Ferrosoferric Oxide - pharmacology
Fever
HeLa Cells
Humans
Hydroxyapatite
Hyperthermia
Identification and classification
Innovations
Iron oxides
Magnetite
Melanoma
Original Research
R&D
Research & development
Skin cancer
Structure-Activity Relationship
Surgery
Surgical implants
Toxicity
Wound Healing - drug effects
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container_title Drug design, development and therapy
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creator Ficai, Denisa
Sonmez, Maria
Albu, Madalina Georgiana
Mihaiescu, Dan Eduard
Ficai, Anton
Bleotu, Coralia
description A layer-by layer technique was successfully used to obtain collagen/hydroxyapatite-magnetite-cisplatin (COLL/HAn-Fe3O4-CisPt, n=1-7) composite materials with a variable content of hydroxyapatite intended for use in the treatment of bone cancer. The main advantages of this system are the possibility of controlling the rate of delivery of cytostatic agents, the presence of collagen and hydroxyapatite to ensure more rapid healing of the injured bone tissue, and the potential for magnetite to be a passive antitumoral component that can be activated when an appropriate external electromagnetic field is applied. In vitro cytotoxicity assays performed on the COLL/HAn-Fe3O4-CisPt materials obtained using a layer-by layer method confirmed their antitumoral activity. Samples with a higher content of hydroxyapatite had more antitumoral activity because of their better absorption of cisplatin and consequently a higher amount of cisplatin being present in the matrices.
doi_str_mv 10.2147/DDDT.S62805
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The main advantages of this system are the possibility of controlling the rate of delivery of cytostatic agents, the presence of collagen and hydroxyapatite to ensure more rapid healing of the injured bone tissue, and the potential for magnetite to be a passive antitumoral component that can be activated when an appropriate external electromagnetic field is applied. In vitro cytotoxicity assays performed on the COLL/HAn-Fe3O4-CisPt materials obtained using a layer-by layer method confirmed their antitumoral activity. 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dosage</topic><topic>Cisplatin - chemistry</topic><topic>Cisplatin - pharmacology</topic><topic>Collagen</topic><topic>Collagen - administration &amp; dosage</topic><topic>Collagen - chemistry</topic><topic>Collagen - pharmacology</topic><topic>Composite materials</topic><topic>Cytostatic agents</topic><topic>Cytotoxicity</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Drug Delivery Systems</topic><topic>Durapatite - administration &amp; dosage</topic><topic>Durapatite - chemistry</topic><topic>Durapatite - pharmacology</topic><topic>Electromagnetic fields</topic><topic>Electromagnetism</topic><topic>Ferrosoferric Oxide - administration &amp; dosage</topic><topic>Ferrosoferric Oxide - chemistry</topic><topic>Ferrosoferric Oxide - pharmacology</topic><topic>Fever</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Hyperthermia</topic><topic>Identification and classification</topic><topic>Innovations</topic><topic>Iron oxides</topic><topic>Magnetite</topic><topic>Melanoma</topic><topic>Original Research</topic><topic>R&amp;D</topic><topic>Research &amp; 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The main advantages of this system are the possibility of controlling the rate of delivery of cytostatic agents, the presence of collagen and hydroxyapatite to ensure more rapid healing of the injured bone tissue, and the potential for magnetite to be a passive antitumoral component that can be activated when an appropriate external electromagnetic field is applied. In vitro cytotoxicity assays performed on the COLL/HAn-Fe3O4-CisPt materials obtained using a layer-by layer method confirmed their antitumoral activity. Samples with a higher content of hydroxyapatite had more antitumoral activity because of their better absorption of cisplatin and consequently a higher amount of cisplatin being present in the matrices.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>25767374</pmid><doi>10.2147/DDDT.S62805</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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ispartof Drug design, development and therapy, 2015-01, Vol.9 (default), p.1269-1279
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subjects Anticancer properties
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biomedical materials
Bone cancer
Bone healing
Bone regeneration
Bone Regeneration - drug effects
Cancer therapies
Care and treatment
Cell Cycle - drug effects
Cell Death - drug effects
Chemotherapy
Chlorine
Cisplatin
Cisplatin - administration & dosage
Cisplatin - chemistry
Cisplatin - pharmacology
Collagen
Collagen - administration & dosage
Collagen - chemistry
Collagen - pharmacology
Composite materials
Cytostatic agents
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
Drug Delivery Systems
Durapatite - administration & dosage
Durapatite - chemistry
Durapatite - pharmacology
Electromagnetic fields
Electromagnetism
Ferrosoferric Oxide - administration & dosage
Ferrosoferric Oxide - chemistry
Ferrosoferric Oxide - pharmacology
Fever
HeLa Cells
Humans
Hydroxyapatite
Hyperthermia
Identification and classification
Innovations
Iron oxides
Magnetite
Melanoma
Original Research
R&D
Research & development
Skin cancer
Structure-Activity Relationship
Surgery
Surgical implants
Toxicity
Wound Healing - drug effects
title Antitumoral materials with regenerative function obtained using a layer-by-layer technique
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