Case report: A patient with mitochondrial neurogastrointestinal encephalomyopathy and chronic intestinal failure

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare disorder commonly diagnosed in later disease stages when it prominently manifests as malnutrition. We report on a female patient diagnosed with MNGIE at the age of 36. She was severely malnourished due to loss of resorptive surf...

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Bibliographic Details
Published in:Frontiers in nutrition (Lausanne) 2022-11, Vol.9
Main Authors: Barisic, Ana, Ljubas Kelecic, Dina, Vranesic Bender, Darija, Karas, Irena, Brinar, Marko, Miletic, Vladimir, Krznaric, Zeljko
Format: Article
Language:English
Subjects:
home parenteral nutrition
intestinal failure
malnutrition
mitochondrial neurogastrointestinal encephalomyopathy
Nutrition
nutrition team
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Summary:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare disorder commonly diagnosed in later disease stages when it prominently manifests as malnutrition. We report on a female patient diagnosed with MNGIE at the age of 36. She was severely malnourished due to loss of resorptive surface after several surgical procedures, gastrointestinal dysmotility, and small intestinal bacterial overgrowth. Therefore, early and aggressive total parenteral nutrition was introduced. Although no reports have shown that nutritional support can modify the clinical outcome, this case suggests that adequate nutritional support, particularly parenteral nutrition, supervised by an experienced nutritional team, may prolong the lifespan of patients with MNGIE.
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2022.983873