A prospective study of nutritional status in immunoglobulin light chain amyloidosis

Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed...

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Bibliographic Details
Published in:Haematologica (Roma) 2013-01, Vol.98 (1), p.136-140
Main Authors: Sattianayagam, Prayman T, Lane, Thirusha, Fox, Zoe, Petrie, Aviva, Gibbs, Simon D J, Pinney, Jennifer H, Risom, Signe S, Rowczenio, Dorota M, Wechalekar, Ashutosh D, Lachmann, Helen J, Gilbertson, Janet A, Hawkins, Philip N, Gillmore, Julian D
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amyloidosis - genetics
Amyloidosis - immunology
Amyloidosis - mortality
Female
Follow-Up Studies
Humans
Immunoglobulin Light Chains - genetics
Male
Middle Aged
Nutritional Status - immunology
Prospective Studies
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Summary:Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2012.070359