Relation between interleukin-6 concentrations and oxidative status of HIV infected patients with /or at risk of Kaposi disease in Yaounde

• Published in: Virology journal 2023-07, Vol.20 (1), p.165-165, Article 165
• Main Authors: Voufo, Roger Ahouga, Kouotou, Armand Emmanuel, Tatah, Nchinda Jones, TeTo, Georges, Gueguim, Cédric, Ngondé, Chantal Marie Essome, Njiguet Tepa, Armand Gabin, Gabin, Arnaud, Amazia, Falmata, Yembeau, Natacha Lena, Kouanfack, Charles, Anatole, Pieme Constant
• Format: Article
• Language: English
• Subjects: Adult; Antibodies; Antigens; Antioxidants; B cells; Biochemistry; Cameroon; Centrifugation; Clinics; Complications and side effects; Consent; Cross-Sectional Studies; Cytokines; Disease; Enzyme-linked immunosorbent assay; Enzymes; Ethics; Glutathione; Health aspects; Herpes viruses; Herpesviridae Infections; Herpesvirus 8, Human; HIV; HIV (Viruses); HIV infection; HIV Infections - complications; HIV patients; HIV-1; Hospitals; Human immunodeficiency virus; Humans; Immunology; Interleukin 6; Interleukins; Kaposi's sarcoma; Kaposi’s disease; Laboratories; Medical research; Medicine, Experimental; Middle Aged; Oxidative status; Oxidative stress; Patients; Population studies; Risk factors; Sarcoma, Kaposi; Sex ratio; Spectrophotometry; Xeroderma Pigmentosum
• ISSN: 1743-422X; 1743-422X
• DOI: 10.1186/s12985-023-02109-9

To investigate the relation between interleukin-6 concentration and oxidative status of HIV infected patients with or at risk of Kaposi's disease in Yaoundé. We conducted a two-months cross-sectional study on 87 consenting HIV infected patients followed at the Day Hospital of the Yaoundé Central Hospital. Serum/plasma obtained after centrifugation of blood collected in dry/EDTA tubes was used for the determination of Human Herpes Virus-8 antigen (HHV-8) and Interleukin-6 (IL-6) by the ELISA technique, and that of oxidative stress markers: Malondialdehyde (MDA) reduced Glutathione (GSH) and total antioxidant capacity by spectrophotometry. Subjects belonging to the [40-50[year-old age group were mainly represented in our study population with 43.7%. The average age was 44.6 ± 10.4 years with extremes ranging from 26 to 72 years. The sex ratio was 0.24. Our population was mainly represented by people infected with HIV type I (90.8%) and 3.4% had developed clinical signs of Kaposi's disease. The prevalence of the HHV-8 antigen was 57.5%. Immune and oxidative parameters did not vary with age, sex and therapeutic line. We noted a significant increase in IL-6 concentrations in patients positive to the HHV-8 antigen for IL-6 concentrations