Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis

This systematic review and meta-analysis study was conducted to estimate the pooled prevalence of CD in low and high risk groups in this region. Following keywords were searched in the Medline, PubMed, Scopus, Web of Science and Cochrane database according to the MeSH terms; celiac disease, prevalen...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.2383-2383, Article 2383
Main Authors: Ashtari, Sara, Najafimehr, Hadis, Pourhoseingholi, Mohamad Amin, Rostami, Kamran, Asadzadeh-Aghdaei, Hamid, Rostami-Nejad, Mohammad, Tavirani, Mostafa Rezaei, Olfatifar, Meysam, Makharia, Govind K., Zali, Mohammad Reza
Format: Article
Language:English
Subjects:
692/308
692/4020
Age Factors
Asia - epidemiology
Autoimmune diseases
Biopsy
Celiac disease
Celiac Disease - epidemiology
Celiac Disease - etiology
Female
Humanities and Social Sciences
Humans
Male
Meta-analysis
multidisciplinary
Population Surveillance
Prevalence
Publication Bias
Risk Assessment
Risk Factors
Risk groups
Science
Science (multidisciplinary)
Seroepidemiologic Studies
Sex Factors
Systematic review
Transglutaminase 2
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Summary:This systematic review and meta-analysis study was conducted to estimate the pooled prevalence of CD in low and high risk groups in this region. Following keywords were searched in the Medline, PubMed, Scopus, Web of Science and Cochrane database according to the MeSH terms; celiac disease, prevalence, high risk population and Asian-Pacific region. Prevalence studies published from January 1991 to March 2018 were selected. Prevalence of CD with 95% confidence interval (CI) was calculated using STATA software, version 14. The pooled sero-prevalence of CD among low risk group in Asia–Pacific region was 1.2% (95% CI 0.8–1.7%) in 96,099 individuals based on positive anti-tissue transglutaminase (anti-t-TG Ab) and/or anti-endomysial antibodies (EMA). The pooled prevalence of biopsy proven CD in Asia–Pacific among high and low risk groups was 4.3% (95% CI 3.3–5.5%) and 0.61% (95% CI 0.4–0.8%) in 10,719 and 70,344 subjects, respectively. In addition, the pooled sero-prevalence and prevalence of CD in general population was significantly higher in children compared with adults and it was significantly greater in female vs. male ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-82023-8