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Predictors of in-hospital mortality in diabetic patients with non-ST-elevation myocardial infarction
Background There have been little data about the additive effects of coronary risk factors on mortality in diabetic patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to evaluate the predictors of mortality in diabetic patients presenting with NSTEMI....
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| Published in: | The Egyptian heart journal 2022-03, Vol.74 (1), p.20-20, Article 20 |
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| container_title | The Egyptian heart journal |
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| creator | Ghorashi, Seyyed Mojtaba Salarifar, Mojtaba Poorhosseini, Hamidreza Sadeghian, Saead Jalali, Arash Aghajani, Hassan Haji-Zeinali, Ali-Mohammad Omidi, Negar |
| description | Background
There have been little data about the additive effects of coronary risk factors on mortality in diabetic patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to evaluate the predictors of mortality in diabetic patients presenting with NSTEMI. All patients admitted to Tehran Heart Center (THC) with a confirmed diagnosis of NSTEMI and a history of diabetes mellitus (DM) type 2 between September 2003 and April 2017 were included. Clinical characteristics and paraclinical data such as lipid profiles, creatinine, hemoglobin, and hemoglobin A1C (HbA1C) were evaluated in these patients to predict in-hospital mortality. The approach for model calibration was a logistic regression with the backward elimination method.
Results
Of a total of 9158 patients with non-ST-segment elevation myocardial infarction, 3133 had diabetes mellitus type 2 and met our criteria to enter the final analysis. In the multivariable analysis, age, chronic obstructive pulmonary disease, and a severely reduced left ventricular ejection fraction (LVEF) significantly increased the rate of in-hospital mortality, whereas mildly and moderately reduced left ventricular ejection fraction did not increase the rate of mortality.
Conclusions
Age, chronic obstructive pulmonary disease (COPD), and severely reduced LVEF ( |
| doi_str_mv | 10.1186/s43044-022-00256-y |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_83d0b03e21b04604ab291249673f1469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A698652234</galeid><doaj_id>oai_doaj_org_article_83d0b03e21b04604ab291249673f1469</doaj_id><sourcerecordid>A698652234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c579t-dbcdbdafb4a9c992fbef3f6f0b1dc0f87f4fcf8780a2d3d810986772344659603</originalsourceid><addsrcrecordid>eNp9Uktr3DAYNKWlCWn-QA_F0EsvSvWybF0KIfQRCLTQFHoTeu5qsaWt5E3Zf99v4zRkodQ-fGI0M3xjT9O8JviCkEG8r5xhzhGmFGFMO4H2z5pTiiVGkpCfz5-cT5rzWjcYHkF7EL1sTljHeM97edq4b8W7aOdcaptDGxNa57qNsx7bKRcYcd4D2rqojZ-jbbd6jj7Ntf0d53WbckLfb5Ef_R3gObXTPltdgD2CKuhiD-ir5kXQY_XnD_Os-fHp4-3VF3Tz9fP11eUNsl0vZ-SMdcbpYLiWVkoajA8siIANcRaHoQ88WBgD1tQxNxAsB9H3lHEuOikwO2uuF1-X9UZtS5x02auso7oHclkpXSDE6NXAHDaYeUoM5gJzbagklEvRs0C4kOD1YfHa7szknYXMRY9Hpsc3Ka7VKt-pATbpKAGDdw8GJf_a-TqrKVbrx1Enn3dVUcG55Jx1A1DfLtSVhtXgu2VwtAe6uhSQsaOQEVgX_2DB6_wUbU4-RMCPBHQR2JJrLT48bk-wOpRILSVSUCJ1XyK1B9Gbp7kfJX8rAwS2ECpcpZUvapN3JcF__Z_tH6vb05Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2644944358</pqid></control><display><type>article</type><title>Predictors of in-hospital mortality in diabetic patients with non-ST-elevation myocardial infarction</title><source>Publicly Available Content Database</source><source>Springer Nature - SpringerLink Journals - Fully Open Access</source><source>PubMed Central</source><creator>Ghorashi, Seyyed Mojtaba ; Salarifar, Mojtaba ; Poorhosseini, Hamidreza ; Sadeghian, Saead ; Jalali, Arash ; Aghajani, Hassan ; Haji-Zeinali, Ali-Mohammad ; Omidi, Negar</creator><creatorcontrib>Ghorashi, Seyyed Mojtaba ; Salarifar, Mojtaba ; Poorhosseini, Hamidreza ; Sadeghian, Saead ; Jalali, Arash ; Aghajani, Hassan ; Haji-Zeinali, Ali-Mohammad ; Omidi, Negar</creatorcontrib><description>Background
There have been little data about the additive effects of coronary risk factors on mortality in diabetic patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to evaluate the predictors of mortality in diabetic patients presenting with NSTEMI. All patients admitted to Tehran Heart Center (THC) with a confirmed diagnosis of NSTEMI and a history of diabetes mellitus (DM) type 2 between September 2003 and April 2017 were included. Clinical characteristics and paraclinical data such as lipid profiles, creatinine, hemoglobin, and hemoglobin A1C (HbA1C) were evaluated in these patients to predict in-hospital mortality. The approach for model calibration was a logistic regression with the backward elimination method.
Results
Of a total of 9158 patients with non-ST-segment elevation myocardial infarction, 3133 had diabetes mellitus type 2 and met our criteria to enter the final analysis. In the multivariable analysis, age, chronic obstructive pulmonary disease, and a severely reduced left ventricular ejection fraction (LVEF) significantly increased the rate of in-hospital mortality, whereas mildly and moderately reduced left ventricular ejection fraction did not increase the rate of mortality.
Conclusions
Age, chronic obstructive pulmonary disease (COPD), and severely reduced LVEF (< 30%) independently increased in-hospital mortality in our diabetic patients with a confirmed diagnosis of NSTEMI. Severely reduced LVEF had the strongest relationship with in-hospital mortality, whereas the mean HbA1C level and the type of DM management exerted no significant effect on in-hospital mortality.</description><identifier>ISSN: 2090-911X</identifier><identifier>ISSN: 1110-2608</identifier><identifier>EISSN: 2090-911X</identifier><identifier>DOI: 10.1186/s43044-022-00256-y</identifier><identifier>PMID: 35347479</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Cardiology ; Clopidogrel ; Diabetes ; Diabetes mellitus ; Diabetics ; Ejection fraction ; Glycosylated hemoglobin ; Heart ; Heart attack ; Iran ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Mortality ; Myocardial infarction ; Patient outcomes ; Prognosis ; Risk factors</subject><ispartof>The Egyptian heart journal, 2022-03, Vol.74 (1), p.20-20, Article 20</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-dbcdbdafb4a9c992fbef3f6f0b1dc0f87f4fcf8780a2d3d810986772344659603</citedby><cites>FETCH-LOGICAL-c579t-dbcdbdafb4a9c992fbef3f6f0b1dc0f87f4fcf8780a2d3d810986772344659603</cites><orcidid>0000-0003-2344-1661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960521/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960521/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35347479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghorashi, Seyyed Mojtaba</creatorcontrib><creatorcontrib>Salarifar, Mojtaba</creatorcontrib><creatorcontrib>Poorhosseini, Hamidreza</creatorcontrib><creatorcontrib>Sadeghian, Saead</creatorcontrib><creatorcontrib>Jalali, Arash</creatorcontrib><creatorcontrib>Aghajani, Hassan</creatorcontrib><creatorcontrib>Haji-Zeinali, Ali-Mohammad</creatorcontrib><creatorcontrib>Omidi, Negar</creatorcontrib><title>Predictors of in-hospital mortality in diabetic patients with non-ST-elevation myocardial infarction</title><title>The Egyptian heart journal</title><addtitle>Egypt Heart J</addtitle><addtitle>Egypt Heart J</addtitle><description>Background
There have been little data about the additive effects of coronary risk factors on mortality in diabetic patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to evaluate the predictors of mortality in diabetic patients presenting with NSTEMI. All patients admitted to Tehran Heart Center (THC) with a confirmed diagnosis of NSTEMI and a history of diabetes mellitus (DM) type 2 between September 2003 and April 2017 were included. Clinical characteristics and paraclinical data such as lipid profiles, creatinine, hemoglobin, and hemoglobin A1C (HbA1C) were evaluated in these patients to predict in-hospital mortality. The approach for model calibration was a logistic regression with the backward elimination method.
Results
Of a total of 9158 patients with non-ST-segment elevation myocardial infarction, 3133 had diabetes mellitus type 2 and met our criteria to enter the final analysis. In the multivariable analysis, age, chronic obstructive pulmonary disease, and a severely reduced left ventricular ejection fraction (LVEF) significantly increased the rate of in-hospital mortality, whereas mildly and moderately reduced left ventricular ejection fraction did not increase the rate of mortality.
Conclusions
Age, chronic obstructive pulmonary disease (COPD), and severely reduced LVEF (< 30%) independently increased in-hospital mortality in our diabetic patients with a confirmed diagnosis of NSTEMI. Severely reduced LVEF had the strongest relationship with in-hospital mortality, whereas the mean HbA1C level and the type of DM management exerted no significant effect on in-hospital mortality.</description><subject>Analysis</subject><subject>Cardiology</subject><subject>Clopidogrel</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetics</subject><subject>Ejection fraction</subject><subject>Glycosylated hemoglobin</subject><subject>Heart</subject><subject>Heart attack</subject><subject>Iran</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Patient outcomes</subject><subject>Prognosis</subject><subject>Risk factors</subject><issn>2090-911X</issn><issn>1110-2608</issn><issn>2090-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9Uktr3DAYNKWlCWn-QA_F0EsvSvWybF0KIfQRCLTQFHoTeu5qsaWt5E3Zf99v4zRkodQ-fGI0M3xjT9O8JviCkEG8r5xhzhGmFGFMO4H2z5pTiiVGkpCfz5-cT5rzWjcYHkF7EL1sTljHeM97edq4b8W7aOdcaptDGxNa57qNsx7bKRcYcd4D2rqojZ-jbbd6jj7Ntf0d53WbckLfb5Ef_R3gObXTPltdgD2CKuhiD-ir5kXQY_XnD_Os-fHp4-3VF3Tz9fP11eUNsl0vZ-SMdcbpYLiWVkoajA8siIANcRaHoQ88WBgD1tQxNxAsB9H3lHEuOikwO2uuF1-X9UZtS5x02auso7oHclkpXSDE6NXAHDaYeUoM5gJzbagklEvRs0C4kOD1YfHa7szknYXMRY9Hpsc3Ka7VKt-pATbpKAGDdw8GJf_a-TqrKVbrx1Enn3dVUcG55Jx1A1DfLtSVhtXgu2VwtAe6uhSQsaOQEVgX_2DB6_wUbU4-RMCPBHQR2JJrLT48bk-wOpRILSVSUCJ1XyK1B9Gbp7kfJX8rAwS2ECpcpZUvapN3JcF__Z_tH6vb05Q</recordid><startdate>20220328</startdate><enddate>20220328</enddate><creator>Ghorashi, Seyyed Mojtaba</creator><creator>Salarifar, Mojtaba</creator><creator>Poorhosseini, Hamidreza</creator><creator>Sadeghian, Saead</creator><creator>Jalali, Arash</creator><creator>Aghajani, Hassan</creator><creator>Haji-Zeinali, Ali-Mohammad</creator><creator>Omidi, Negar</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>SpringerOpen</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2344-1661</orcidid></search><sort><creationdate>20220328</creationdate><title>Predictors of in-hospital mortality in diabetic patients with non-ST-elevation myocardial infarction</title><author>Ghorashi, Seyyed Mojtaba ; Salarifar, Mojtaba ; Poorhosseini, Hamidreza ; Sadeghian, Saead ; Jalali, Arash ; Aghajani, Hassan ; Haji-Zeinali, Ali-Mohammad ; Omidi, Negar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-dbcdbdafb4a9c992fbef3f6f0b1dc0f87f4fcf8780a2d3d810986772344659603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Cardiology</topic><topic>Clopidogrel</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetics</topic><topic>Ejection fraction</topic><topic>Glycosylated hemoglobin</topic><topic>Heart</topic><topic>Heart attack</topic><topic>Iran</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Patient outcomes</topic><topic>Prognosis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghorashi, Seyyed Mojtaba</creatorcontrib><creatorcontrib>Salarifar, Mojtaba</creatorcontrib><creatorcontrib>Poorhosseini, Hamidreza</creatorcontrib><creatorcontrib>Sadeghian, Saead</creatorcontrib><creatorcontrib>Jalali, Arash</creatorcontrib><creatorcontrib>Aghajani, Hassan</creatorcontrib><creatorcontrib>Haji-Zeinali, Ali-Mohammad</creatorcontrib><creatorcontrib>Omidi, Negar</creatorcontrib><collection>SpringerOpen</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Egyptian heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghorashi, Seyyed Mojtaba</au><au>Salarifar, Mojtaba</au><au>Poorhosseini, Hamidreza</au><au>Sadeghian, Saead</au><au>Jalali, Arash</au><au>Aghajani, Hassan</au><au>Haji-Zeinali, Ali-Mohammad</au><au>Omidi, Negar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of in-hospital mortality in diabetic patients with non-ST-elevation myocardial infarction</atitle><jtitle>The Egyptian heart journal</jtitle><stitle>Egypt Heart J</stitle><addtitle>Egypt Heart J</addtitle><date>2022-03-28</date><risdate>2022</risdate><volume>74</volume><issue>1</issue><spage>20</spage><epage>20</epage><pages>20-20</pages><artnum>20</artnum><issn>2090-911X</issn><issn>1110-2608</issn><eissn>2090-911X</eissn><abstract>Background
There have been little data about the additive effects of coronary risk factors on mortality in diabetic patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to evaluate the predictors of mortality in diabetic patients presenting with NSTEMI. All patients admitted to Tehran Heart Center (THC) with a confirmed diagnosis of NSTEMI and a history of diabetes mellitus (DM) type 2 between September 2003 and April 2017 were included. Clinical characteristics and paraclinical data such as lipid profiles, creatinine, hemoglobin, and hemoglobin A1C (HbA1C) were evaluated in these patients to predict in-hospital mortality. The approach for model calibration was a logistic regression with the backward elimination method.
Results
Of a total of 9158 patients with non-ST-segment elevation myocardial infarction, 3133 had diabetes mellitus type 2 and met our criteria to enter the final analysis. In the multivariable analysis, age, chronic obstructive pulmonary disease, and a severely reduced left ventricular ejection fraction (LVEF) significantly increased the rate of in-hospital mortality, whereas mildly and moderately reduced left ventricular ejection fraction did not increase the rate of mortality.
Conclusions
Age, chronic obstructive pulmonary disease (COPD), and severely reduced LVEF (< 30%) independently increased in-hospital mortality in our diabetic patients with a confirmed diagnosis of NSTEMI. Severely reduced LVEF had the strongest relationship with in-hospital mortality, whereas the mean HbA1C level and the type of DM management exerted no significant effect on in-hospital mortality.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35347479</pmid><doi>10.1186/s43044-022-00256-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2344-1661</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The Egyptian heart journal, 2022-03, Vol.74 (1), p.20-20, Article 20 |
| issn | 2090-911X 1110-2608 2090-911X |
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| source | Publicly Available Content Database; Springer Nature - SpringerLink Journals - Fully Open Access; PubMed Central |
| subjects | Analysis Cardiology Clopidogrel Diabetes Diabetes mellitus Diabetics Ejection fraction Glycosylated hemoglobin Heart Heart attack Iran Medical research Medicine Medicine & Public Health Medicine, Experimental Mortality Myocardial infarction Patient outcomes Prognosis Risk factors |
| title | Predictors of in-hospital mortality in diabetic patients with non-ST-elevation myocardial infarction |
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