Soft Contact Lenses as Drug Delivery Systems: A Review

This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literatur...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-09, Vol.26 (18), p.5577
Main Authors: Rykowska, Iwona, Nowak, Iwona, Nowak, Rafał
Format: Article
Language:English
Subjects:
Bioavailability
Biofilms
Chemical compounds
Contact angle
Contact lenses
Contact Lenses, Hydrophilic
Cornea
Design
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
drug delivery systems based on contact lenses in ophthalmic therapies
drug-controlled release
Drugs
Eye
Eye diseases
Eye Diseases - drug therapy
Eye Diseases - therapy
Humans
Hydrogels
Interdisciplinary studies
Ophthalmic Solutions - administration & dosage
Patient compliance
Permeability
Pharmacology
Physical properties
Physiology
Polymers
Review
Tears
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Summary:This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26185577