CD4+ cell counts in patients with different clinical manifestations of tuberculosis

Tuberculosis is the prototype of infections that require a cellular immune response for their control. It has been shown that CD4+ T-lymphocytes are most important in the protective response against Mycobacterium tuberculosis. CD8+ T-lymphocytes are also important for effective T-cell immune respons...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2008-12, Vol.12 (6), p.483-486
Main Authors: Davoudi, Setareh, Rasoolinegad, Mehrnaz, Younesian, Masoud, Hajiabdolbaghi, Mahboubeh, Soudbakhsh, Abdolreza, Jafari, Sirous, EmadiKouchak, Hamid, Mehrpouya, Morteza, Lotfi, Hossein
Format: Article
Language:English
Subjects:
Adult
Biological response modifiers
Care and treatment
Case-Control Studies
CD4
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Clinical medicine
Development and progression
Female
Flow Cytometry
Humans
Immune response
Immunity, Cellular
Immunotherapy
INFECTIOUS DISEASES
Male
Methods
Middle Aged
Mycobacterium tuberculosis
Observations
Properties
T cells
Tuberculosis
Tuberculosis - immunology
Tuberculosis, Lymph Node - immunology
Tuberculosis, Meningeal - immunology
Tuberculosis, Miliary - immunology
Tuberculosis, Pulmonary - immunology
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Summary:Tuberculosis is the prototype of infections that require a cellular immune response for their control. It has been shown that CD4+ T-lymphocytes are most important in the protective response against Mycobacterium tuberculosis. CD8+ T-lymphocytes are also important for effective T-cell immune response. This study compares CD4+ and CD8+ baseline values in patients with different manifestations of tuberculosis. CD4+ and CD8+ in three groups of patients with tuberculosis (pulmonary, lymphadenitis, meningitis/milliary involvement) and a group of healthy volunteers were enumerated using flowcytometry. Twenty-six patients with pulmonary tuberculosis, 10 with adenitis, 16 with meningitis or milliary tuberculosis and 16 healthy volunteers entered the study. Mean CD4 in meningitis/milliary group was significantly lower than all other groups (p
ISSN:1413-8670
1678-4391
1678-4391
DOI:10.1590/S1413-86702008000600008