Influence of Branched Polyester Chains on the Emission Behavior of Dipyridamole Molecule and Its Biosensing Ability

Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly­(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring...

Full description

Saved in:
Bibliographic Details
Published in:ACS omega 2018-11, Vol.3 (11), p.15530-15537
Main Authors: Nagarajan, Selvaraj, Sankar, Vandana, Bejoymohandas, Kochan Sathyaseelan, Duan, Yongxin, Zhang, Jianming
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3
cites cdi_FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3
container_end_page 15537
container_issue 11
container_start_page 15530
container_title ACS omega
container_volume 3
creator Nagarajan, Selvaraj
Sankar, Vandana
Bejoymohandas, Kochan Sathyaseelan
Duan, Yongxin
Zhang, Jianming
description Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly­(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring-opening polymerization. After polymerization, the influence of the polyester chains on the Dip emission behavior has been studied systematically in this work. Dip–PLLA has undergone CO···NC interaction in ground stage, leading to intramolecular charge transfer in the excited state. Limited availability of the CO in PCL chains resists such interactions with Dip molecule. So, this structural availability of the CO group in the polymeric chains influences the color change between Dip–PLLA (green fluorescence) and Dip–PCL (blue fluorescence). To visualize the biosensing ability of Dip–PLLA and Dip–PCL, hollow microspheres have been prepared by the double-emulsion solvent evaporation method, and the prepared microspheres cells uptake has been visualized by fluorescence imaging.
doi_str_mv 10.1021/acsomega.8b01436
format article
fullrecord <record><control><sourceid>acs_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_83e39ad2e5324f8aa619503220a26489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_83e39ad2e5324f8aa619503220a26489</doaj_id><sourcerecordid>d151087648</sourcerecordid><originalsourceid>FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3</originalsourceid><addsrcrecordid>eNp1kc1u3CAURq2qUROl2XdV8QCdlD_bsKmUmabtSKmSRbpG13A9ZmTDCDyR5u1LOkmULLqBC9xzEHxV9YnRS0Y5-wo2xwk3cKk6yqRo3lVnXLZ0wYQU71_Vp9VFzltKKWsUV7z5UJ0KWtcNpeqsyuvQj3sMFknsyTJBsAM6chfHA-YZE1kN4EMmMZB5QHI9-Zx9WSxxgAcf0yP13e8OyTuY4ojkdxnsvhQQHFnPmSx9zBiyDxty1fnRz4eP1UkPY8aLp_m8-vPj-n71a3Fz-3O9urpZgNR6XqDm4HSrFNYWXHkk71pU1GnNsGNOguSSQ0-dlKzWjW3aTray1koI1jHdi_NqffS6CFuzS36CdDARvPm3EdPGQJq9HdEogUKD41gLLnsF0DBdU8E5Bd5IpYvr29G123cTOothTjC-kb49CX4wm_hgGq5Uq2gR0KPApphzwv6FZdQ85mme8zRPeRbk8-s7X4Dn9ErDl2NDQc027lMo3_l_318R4K1m</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Influence of Branched Polyester Chains on the Emission Behavior of Dipyridamole Molecule and Its Biosensing Ability</title><source>American Chemical Society (ACS) Open Access</source><source>PubMed Central</source><creator>Nagarajan, Selvaraj ; Sankar, Vandana ; Bejoymohandas, Kochan Sathyaseelan ; Duan, Yongxin ; Zhang, Jianming</creator><creatorcontrib>Nagarajan, Selvaraj ; Sankar, Vandana ; Bejoymohandas, Kochan Sathyaseelan ; Duan, Yongxin ; Zhang, Jianming</creatorcontrib><description>Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly­(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring-opening polymerization. After polymerization, the influence of the polyester chains on the Dip emission behavior has been studied systematically in this work. Dip–PLLA has undergone CO···NC interaction in ground stage, leading to intramolecular charge transfer in the excited state. Limited availability of the CO in PCL chains resists such interactions with Dip molecule. So, this structural availability of the CO group in the polymeric chains influences the color change between Dip–PLLA (green fluorescence) and Dip–PCL (blue fluorescence). To visualize the biosensing ability of Dip–PLLA and Dip–PCL, hollow microspheres have been prepared by the double-emulsion solvent evaporation method, and the prepared microspheres cells uptake has been visualized by fluorescence imaging.</description><identifier>ISSN: 2470-1343</identifier><identifier>EISSN: 2470-1343</identifier><identifier>DOI: 10.1021/acsomega.8b01436</identifier><identifier>PMID: 30556008</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><ispartof>ACS omega, 2018-11, Vol.3 (11), p.15530-15537</ispartof><rights>Copyright © 2018 American Chemical Society 2018 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3</citedby><cites>FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3</cites><orcidid>0000-0003-3388-4941 ; 0000-0002-0252-4516 ; 0000-0001-6707-3165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsomega.8b01436$$EPDF$$P50$$Gacs$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsomega.8b01436$$EHTML$$P50$$Gacs$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27080,27924,27925,53791,53793,56762,56812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30556008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagarajan, Selvaraj</creatorcontrib><creatorcontrib>Sankar, Vandana</creatorcontrib><creatorcontrib>Bejoymohandas, Kochan Sathyaseelan</creatorcontrib><creatorcontrib>Duan, Yongxin</creatorcontrib><creatorcontrib>Zhang, Jianming</creatorcontrib><title>Influence of Branched Polyester Chains on the Emission Behavior of Dipyridamole Molecule and Its Biosensing Ability</title><title>ACS omega</title><addtitle>ACS Omega</addtitle><description>Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly­(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring-opening polymerization. After polymerization, the influence of the polyester chains on the Dip emission behavior has been studied systematically in this work. Dip–PLLA has undergone CO···NC interaction in ground stage, leading to intramolecular charge transfer in the excited state. Limited availability of the CO in PCL chains resists such interactions with Dip molecule. So, this structural availability of the CO group in the polymeric chains influences the color change between Dip–PLLA (green fluorescence) and Dip–PCL (blue fluorescence). To visualize the biosensing ability of Dip–PLLA and Dip–PCL, hollow microspheres have been prepared by the double-emulsion solvent evaporation method, and the prepared microspheres cells uptake has been visualized by fluorescence imaging.</description><issn>2470-1343</issn><issn>2470-1343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>N~.</sourceid><sourceid>DOA</sourceid><recordid>eNp1kc1u3CAURq2qUROl2XdV8QCdlD_bsKmUmabtSKmSRbpG13A9ZmTDCDyR5u1LOkmULLqBC9xzEHxV9YnRS0Y5-wo2xwk3cKk6yqRo3lVnXLZ0wYQU71_Vp9VFzltKKWsUV7z5UJ0KWtcNpeqsyuvQj3sMFknsyTJBsAM6chfHA-YZE1kN4EMmMZB5QHI9-Zx9WSxxgAcf0yP13e8OyTuY4ojkdxnsvhQQHFnPmSx9zBiyDxty1fnRz4eP1UkPY8aLp_m8-vPj-n71a3Fz-3O9urpZgNR6XqDm4HSrFNYWXHkk71pU1GnNsGNOguSSQ0-dlKzWjW3aTray1koI1jHdi_NqffS6CFuzS36CdDARvPm3EdPGQJq9HdEogUKD41gLLnsF0DBdU8E5Bd5IpYvr29G123cTOothTjC-kb49CX4wm_hgGq5Uq2gR0KPApphzwv6FZdQ85mme8zRPeRbk8-s7X4Dn9ErDl2NDQc027lMo3_l_318R4K1m</recordid><startdate>20181130</startdate><enddate>20181130</enddate><creator>Nagarajan, Selvaraj</creator><creator>Sankar, Vandana</creator><creator>Bejoymohandas, Kochan Sathyaseelan</creator><creator>Duan, Yongxin</creator><creator>Zhang, Jianming</creator><general>American Chemical Society</general><scope>N~.</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3388-4941</orcidid><orcidid>https://orcid.org/0000-0002-0252-4516</orcidid><orcidid>https://orcid.org/0000-0001-6707-3165</orcidid></search><sort><creationdate>20181130</creationdate><title>Influence of Branched Polyester Chains on the Emission Behavior of Dipyridamole Molecule and Its Biosensing Ability</title><author>Nagarajan, Selvaraj ; Sankar, Vandana ; Bejoymohandas, Kochan Sathyaseelan ; Duan, Yongxin ; Zhang, Jianming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagarajan, Selvaraj</creatorcontrib><creatorcontrib>Sankar, Vandana</creatorcontrib><creatorcontrib>Bejoymohandas, Kochan Sathyaseelan</creatorcontrib><creatorcontrib>Duan, Yongxin</creatorcontrib><creatorcontrib>Zhang, Jianming</creatorcontrib><collection>American Chemical Society (ACS) Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>ACS omega</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagarajan, Selvaraj</au><au>Sankar, Vandana</au><au>Bejoymohandas, Kochan Sathyaseelan</au><au>Duan, Yongxin</au><au>Zhang, Jianming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Branched Polyester Chains on the Emission Behavior of Dipyridamole Molecule and Its Biosensing Ability</atitle><jtitle>ACS omega</jtitle><addtitle>ACS Omega</addtitle><date>2018-11-30</date><risdate>2018</risdate><volume>3</volume><issue>11</issue><spage>15530</spage><epage>15537</epage><pages>15530-15537</pages><issn>2470-1343</issn><eissn>2470-1343</eissn><abstract>Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly­(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring-opening polymerization. After polymerization, the influence of the polyester chains on the Dip emission behavior has been studied systematically in this work. Dip–PLLA has undergone CO···NC interaction in ground stage, leading to intramolecular charge transfer in the excited state. Limited availability of the CO in PCL chains resists such interactions with Dip molecule. So, this structural availability of the CO group in the polymeric chains influences the color change between Dip–PLLA (green fluorescence) and Dip–PCL (blue fluorescence). To visualize the biosensing ability of Dip–PLLA and Dip–PCL, hollow microspheres have been prepared by the double-emulsion solvent evaporation method, and the prepared microspheres cells uptake has been visualized by fluorescence imaging.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>30556008</pmid><doi>10.1021/acsomega.8b01436</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3388-4941</orcidid><orcidid>https://orcid.org/0000-0002-0252-4516</orcidid><orcidid>https://orcid.org/0000-0001-6707-3165</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2470-1343
ispartof ACS omega, 2018-11, Vol.3 (11), p.15530-15537
issn 2470-1343
2470-1343
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_83e39ad2e5324f8aa619503220a26489
source American Chemical Society (ACS) Open Access; PubMed Central
title Influence of Branched Polyester Chains on the Emission Behavior of Dipyridamole Molecule and Its Biosensing Ability
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A20%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-acs_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Branched%20Polyester%20Chains%20on%20the%20Emission%20Behavior%20of%20Dipyridamole%20Molecule%20and%20Its%20Biosensing%20Ability&rft.jtitle=ACS%20omega&rft.au=Nagarajan,%20Selvaraj&rft.date=2018-11-30&rft.volume=3&rft.issue=11&rft.spage=15530&rft.epage=15537&rft.pages=15530-15537&rft.issn=2470-1343&rft.eissn=2470-1343&rft_id=info:doi/10.1021/acsomega.8b01436&rft_dat=%3Cacs_doaj_%3Ed151087648%3C/acs_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a499t-e92ad9788e5cad8b02b7e80d991eb1d4a4242af0d441596c67b474598331b19f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/30556008&rfr_iscdi=true