Sex-specific associations between serum lipids and hemostatic factors: the cross-sectional population-based KORA-fit study

• Published in: Lipids in health and disease 2022-12, Vol.21 (1), p.143-143, Article 143
• Main Authors: von Falckenstein, Johannes Vogel, Freuer, Dennis, Peters, Annette, Heier, Margit, Teupser, Daniel, Linseisen, Jakob, Meisinger, Christa
• Format: Article
• Language: English
• Subjects: Analysis and chemistry; Blood; Blood coagulation; Blood Coagulation Factors - metabolism; Blood coagulation tests; Cardiovascular diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Demographic aspects; Factor VIII; Female; Fibrinogen - analysis; General population; Health aspects; Hemostasis; Humans; KORA study; Lipid Metabolism - physiology; Lipids - blood; Lipoproteins; Male; Middle Aged; Protein C; Risk Factors; Serum lipids; Sex Characteristics; Sex differences; Triglycerides
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-022-01757-0

Studies on the associations between lipid parameters and different hemostatic factors in men and women from the general population are scarce. It was therefore examined whether there are possible relationships between routinely measured serum lipids (total cholesterol, HDL-cholesterol, non-HDL-cholesterol, LDL-cholesterol, and triglycerides) and different hemostatic factors (activated partial thromboplastin time (aPTT), fibrinogen, factor VIII, antithrombin III (AT III), protein C, protein S, and D-dimer). The analysis was based on data from the Cooperative Health Research in the Region of Augsburg (KORA)-Fit study, which included 805 participants (378 men, 427 women) with a mean age of 63.1 years. Sex-specific associations between serum lipids and coagulation factors were investigated using multivariable linear regression models. In men, total cholesterol was inversely related to aPTT but positively associated with protein C activity. HDL cholesterol was inversely related to aPTT and fibrinogen. LDL cholesterol, non-HDL cholesterol, and triglycerides showed a positive association with protein C and protein S activity. In women, LDL-cholesterol, total cholesterol, and non-HDL-cholesterol were positively related to AT III concentrations and protein C and S activity. Additionally, non-HDL-cholesterol was positively associated with factor VIII activity. HDL cholesterol was inversely related to fibrinogen. Triglycerides showed a positive relationship with protein C activity. There seem to be sex differences regarding various associations between blood lipid levels and hemostatic factors. Further studies are needed to address the possible impact of these associations on cardiovascular risk and the underlying mechanisms.