White matter and nigral alterations in multiple system atrophy-parkinsonian type

Multiple system atrophy (MSA) is classified into two main types: parkinsonian and cerebellar ataxia with oligodendrogliopathy. We examined microstructural alterations in the white matter and the substantia nigra pars compacta (SNc) of patients with MSA of parkinsonian type (MSA-P) using multishell d...

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Published in:NPJ Parkinson's Disease 2021-10, Vol.7 (1), p.96-96, Article 96
Main Authors: Ogawa, Takashi, Hatano, Taku, Kamagata, Koji, Andica, Christina, Takeshige-Amano, Haruka, Uchida, Wataru, Kamiyama, Daiki, Shimo, Yasushi, Oyama, Genko, Umemura, Atsushi, Iwamuro, Hirokazu, Ito, Masanobu, Hori, Masaaki, Aoki, Shigeki, Hattori, Nobutaka
Format: Article
Language:English
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631/378/1689/1718
692/53/2423
Atrophy
Biomedical and Life Sciences
Biomedicine
Magnetic resonance imaging
Medicine
Neurology
Neurosciences
Parkinson's disease
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Summary:Multiple system atrophy (MSA) is classified into two main types: parkinsonian and cerebellar ataxia with oligodendrogliopathy. We examined microstructural alterations in the white matter and the substantia nigra pars compacta (SNc) of patients with MSA of parkinsonian type (MSA-P) using multishell diffusion magnetic resonance imaging (dMRI) and myelin sensitive imaging techniques. Age- and sex-matched patients with MSA-P ( n  = 21, n  = 10 first and second cohorts, respectively), Parkinson’s disease patients ( n  = 19, 17), and healthy controls ( n  = 20, 24) were enrolled. Magnetization transfer saturation imaging (MT-sat) and dMRI were obtained using 3-T MRI. Measurements obtained from diffusion tensor imaging (DTI), free-water elimination DTI, neurite orientation dispersion and density imaging (NODDI), and MT-sat were compared between groups. Tract-based spatial statistics analysis revealed differences in diffuse white matter alterations in the free-water fractional volume, myelin volume fraction, and intracellular volume fraction between the patients with MSA-P and healthy controls, whereas free-water and MT-sat differences were limited to the middle cerebellar peduncle in comparison with those with Parkinson’s disease. Region-of-interest analysis of white matter and SNc revealed significant differences in the middle and inferior cerebellar peduncle, pontine crossing tract, corticospinal tract, and SNc between the MSA-P and healthy controls and/or Parkinson’s disease patients. Our results shed light on alterations to brain microstructure in MSA.
ISSN:2373-8057
2373-8057
DOI:10.1038/s41531-021-00236-0