SISTEMA: A large and standardized collection of transcriptome data sets for human pluripotent stem cell research

• Published in: iScience 2021-07, Vol.24 (7), p.102767, Article 102767
• Main Authors: Jarrige, Margot, Polvèche, Hélène, Carteron, Alexandre, Janczarski, Stéphane, Peschanski, Marc, Auboeuf, Didier, Martinat, Cécile
• Format: Article
• Language: English
• Subjects: Human Pluripotent Stem Cells; Life Sciences; Transcriptomic
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2021.102767

Human pluripotent stem cells have ushered in an exciting new era for disease modeling, drug discovery, and cell therapy development. Continued progress toward realizing the potential of human pluripotent stem cells will be facilitated by robust data sets and complementary resources that are easily accessed and interrogated by the stem cell community. In this context, we present SISTEMA, a quality-controlled curated gene expression database, built on a valuable catalog of human pluripotent stem cell lines, and their derivatives for which transcriptomic analyses have been generated using a single experimental pipeline. SISTEMA functions as a one-step resource that will assist the stem cell community to easily evaluate the expression level for genes of interest, while comparing them across different hPSC lines, cell types, pathological conditions, or after pharmacological treatments. [Display omitted] •SISTEMA is a curated gene expression database using human pluripotent stem cell lines•A single experimental and analytical pipeline are used for the transcriptomic analyses•SISTEMA is a user friendly Web portal designed for the stem cell community Pathophysiology; Cell biology; Stem cells research; Transcriptomics