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The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal
Mosquitoes belonging to the Anopheles gambiae complex are the main vectors of malaria in sub-Saharan Africa. Among these, An. gambiae, Anopheles coluzzii and Anopheles arabiensis are the most efficient vectors and are largely distributed in sympatric locations. However, these species present ecologi...
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Published in: | Malaria journal 2017-08, Vol.16 (1), p.337-337, Article 337 |
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description | Mosquitoes belonging to the Anopheles gambiae complex are the main vectors of malaria in sub-Saharan Africa. Among these, An. gambiae, Anopheles coluzzii and Anopheles arabiensis are the most efficient vectors and are largely distributed in sympatric locations. However, these species present ecological and behavioural differences that impact their vectorial capacity and complicate vector-control efforts, mainly based on long-lasting insecticidal bed nets (LLINs) and indoor residual spraying (IRS). In this study, the genetic structure of these three species in a Senegalese village (Dielmo) was investigated using microsatellite data in samples collected in 2006 before implementation of LLINs, in 2008, when they were introduced, and in 2010, 2 years after the use of LLINs.
In this study 611 individuals were included, namely 136 An. coluzzii, 101 An. gambiae, 6 An. coluzzii/An. gambiae hybrids and 368 An. arabiensis. According to the species, the effect of the implementation of LLINs in Dielmo is differentiated. Populations of the sister species An. coluzzii and An. gambiae regularly experienced bottleneck events, but without significant inbreeding. The Fst values suggested in 2006 a breakdown of assortative mating resulting in hybrids, but the introduction of LLINs was followed by a decrease in the number of hybrids. This suggests a decrease in mating success of hybrids, ecological maladaptation, or a lesser probability of mating between species due to a decrease in An. coluzzii population size. By contrast, the introduction of LLINs has favoured the sibling species An. arabiensis. In this study, some spatial and temporal structuration between An. arabiensis populations were detected, especially in 2008, and the higher genetic diversity observed could result from a diversifying selection.
This work demonstrates the complexity of the malaria context and shows the need to study the genetic structure of Anopheles populations to evaluate the effectiveness of vector-control tools and successful management of malaria vector control. |
doi_str_mv | 10.1186/s12936-017-1992-8 |
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In this study 611 individuals were included, namely 136 An. coluzzii, 101 An. gambiae, 6 An. coluzzii/An. gambiae hybrids and 368 An. arabiensis. According to the species, the effect of the implementation of LLINs in Dielmo is differentiated. Populations of the sister species An. coluzzii and An. gambiae regularly experienced bottleneck events, but without significant inbreeding. The Fst values suggested in 2006 a breakdown of assortative mating resulting in hybrids, but the introduction of LLINs was followed by a decrease in the number of hybrids. This suggests a decrease in mating success of hybrids, ecological maladaptation, or a lesser probability of mating between species due to a decrease in An. coluzzii population size. By contrast, the introduction of LLINs has favoured the sibling species An. arabiensis. In this study, some spatial and temporal structuration between An. arabiensis populations were detected, especially in 2008, and the higher genetic diversity observed could result from a diversifying selection.
This work demonstrates the complexity of the malaria context and shows the need to study the genetic structure of Anopheles populations to evaluate the effectiveness of vector-control tools and successful management of malaria vector control.</description><identifier>ISSN: 1475-2875</identifier><identifier>EISSN: 1475-2875</identifier><identifier>DOI: 10.1186/s12936-017-1992-8</identifier><identifier>PMID: 28810861</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>An. coluzzii and An. arabiensis ; An. gambiae ; Animal genetics ; Animals ; Anopheles ; Anopheles - drug effects ; Anopheles - genetics ; Anopheles gambiae ; Aquatic insects ; Assortative mating ; Bias ; Chromosomes ; Control ; Deoxyribonucleic acid ; DNA ; Gene Flow - drug effects ; Genetic aspects ; Genetic diversity ; Genetic structure ; Genetic variation ; Genetic Variation - drug effects ; Genetics ; Health aspects ; Human diseases ; Human health and pathology ; Hybridization, Genetic - drug effects ; Hybrids ; Inbreeding ; Infectious diseases ; Insecticide-Treated Bednets - utilization ; Insecticides ; Insecticides - pharmacology ; Life Sciences ; LLINs ; Malaria ; Mating ; Microsatellite Repeats - drug effects ; Microsatellites ; Mosquito Control ; Mosquitoes ; Nets ; Outdoors ; Population genetics ; Population number ; Probability theory ; Reproductive behaviour ; Senegal ; Sibling species ; Species Specificity ; Studies ; Sympatric populations ; Vector-borne diseases ; Vectors</subject><ispartof>Malaria journal, 2017-08, Vol.16 (1), p.337-337, Article 337</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-13ef73073f5aaa6a89d9669a7ad7c3ea4be8877baf52b65bf00034107f96d2263</citedby><cites>FETCH-LOGICAL-c594t-13ef73073f5aaa6a89d9669a7ad7c3ea4be8877baf52b65bf00034107f96d2263</cites><orcidid>0000-0002-0683-153X ; 0000-0003-4810-8232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558778/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2348266349?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28810861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01730960$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sougoufara, Seynabou</creatorcontrib><creatorcontrib>Sokhna, Cheikh</creatorcontrib><creatorcontrib>Diagne, Nafissatou</creatorcontrib><creatorcontrib>Doucouré, Souleymane</creatorcontrib><creatorcontrib>Sembène, Pape MBacké</creatorcontrib><creatorcontrib>Harry, Myriam</creatorcontrib><title>The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal</title><title>Malaria journal</title><addtitle>Malar J</addtitle><description>Mosquitoes belonging to the Anopheles gambiae complex are the main vectors of malaria in sub-Saharan Africa. Among these, An. gambiae, Anopheles coluzzii and Anopheles arabiensis are the most efficient vectors and are largely distributed in sympatric locations. However, these species present ecological and behavioural differences that impact their vectorial capacity and complicate vector-control efforts, mainly based on long-lasting insecticidal bed nets (LLINs) and indoor residual spraying (IRS). In this study, the genetic structure of these three species in a Senegalese village (Dielmo) was investigated using microsatellite data in samples collected in 2006 before implementation of LLINs, in 2008, when they were introduced, and in 2010, 2 years after the use of LLINs.
In this study 611 individuals were included, namely 136 An. coluzzii, 101 An. gambiae, 6 An. coluzzii/An. gambiae hybrids and 368 An. arabiensis. According to the species, the effect of the implementation of LLINs in Dielmo is differentiated. Populations of the sister species An. coluzzii and An. gambiae regularly experienced bottleneck events, but without significant inbreeding. The Fst values suggested in 2006 a breakdown of assortative mating resulting in hybrids, but the introduction of LLINs was followed by a decrease in the number of hybrids. This suggests a decrease in mating success of hybrids, ecological maladaptation, or a lesser probability of mating between species due to a decrease in An. coluzzii population size. By contrast, the introduction of LLINs has favoured the sibling species An. arabiensis. In this study, some spatial and temporal structuration between An. arabiensis populations were detected, especially in 2008, and the higher genetic diversity observed could result from a diversifying selection.
This work demonstrates the complexity of the malaria context and shows the need to study the genetic structure of Anopheles populations to evaluate the effectiveness of vector-control tools and successful management of malaria vector control.</description><subject>An. coluzzii and An. arabiensis</subject><subject>An. gambiae</subject><subject>Animal genetics</subject><subject>Animals</subject><subject>Anopheles</subject><subject>Anopheles - drug effects</subject><subject>Anopheles - genetics</subject><subject>Anopheles gambiae</subject><subject>Aquatic insects</subject><subject>Assortative mating</subject><subject>Bias</subject><subject>Chromosomes</subject><subject>Control</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gene Flow - drug effects</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic structure</subject><subject>Genetic variation</subject><subject>Genetic Variation - drug effects</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Human diseases</subject><subject>Human health and pathology</subject><subject>Hybridization, Genetic - drug effects</subject><subject>Hybrids</subject><subject>Inbreeding</subject><subject>Infectious diseases</subject><subject>Insecticide-Treated Bednets - utilization</subject><subject>Insecticides</subject><subject>Insecticides - pharmacology</subject><subject>Life Sciences</subject><subject>LLINs</subject><subject>Malaria</subject><subject>Mating</subject><subject>Microsatellite Repeats - drug effects</subject><subject>Microsatellites</subject><subject>Mosquito Control</subject><subject>Mosquitoes</subject><subject>Nets</subject><subject>Outdoors</subject><subject>Population genetics</subject><subject>Population number</subject><subject>Probability theory</subject><subject>Reproductive behaviour</subject><subject>Senegal</subject><subject>Sibling species</subject><subject>Species Specificity</subject><subject>Studies</subject><subject>Sympatric populations</subject><subject>Vector-borne diseases</subject><subject>Vectors</subject><issn>1475-2875</issn><issn>1475-2875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqXwA7ggS1xAIsUfieNcKq3KRyutxIFytibOOOuVEy92toIfx3_DYUtpK5SDrZn3fWY8maJ4yegpY0q-T4y3QpaUNSVrW16qR8Uxq5q65KqpH9-5HxXPUtrSLFQNf1occaUYVZIdF7-uNkjcuPM44jTD7MJEgiU-TEPpIc1uGoibEprZGdeDJx32ZMI5kQ0k0jtrMWajyxnMd5MTmTBn6IBZ5gxJc9ybeR9x4S6JlY3OwERG8BAdkOvsCjHlMof0FHYb9JjIAGPnAIkJS38_FsEHh34M78jXDB_APy-eWPAJX9ycJ8W3Tx-vzi_K9ZfPl-erdWnqtppLJtA2gjbC1gAgQbV9K2ULDfSNEQhVh0o1TQe25p2sO0spFRWjjW1lz7kUJ8XlgdsH2OpddCPEnzqA038CIQ4aYn6sR61yrUrZThirql5SUFBRkGio6TrFWWadHVi7fTdib_L0Ivh70PuZyW30EK51Xde5SZUBbw-AzQPbxWqtl1j-zYK2kl4vxd7cFIvh-x7TrEeXDHoPE4Z90qzlbUsZY1WWvn4g3YZ9nPJYNReV4lKKqv2nytNH7SYbco9mgepVzRhXQrCl7Ol_VPnrcXQmTGhdjt8zsIPBxJBSRHv7MEb1suv6sOvL2_Sy63qZw6u7g7x1_F1u8RvlZvvo</recordid><startdate>20170815</startdate><enddate>20170815</enddate><creator>Sougoufara, Seynabou</creator><creator>Sokhna, Cheikh</creator><creator>Diagne, Nafissatou</creator><creator>Doucouré, Souleymane</creator><creator>Sembène, Pape MBacké</creator><creator>Harry, Myriam</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0683-153X</orcidid><orcidid>https://orcid.org/0000-0003-4810-8232</orcidid></search><sort><creationdate>20170815</creationdate><title>The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal</title><author>Sougoufara, Seynabou ; Sokhna, Cheikh ; Diagne, Nafissatou ; Doucouré, Souleymane ; Sembène, Pape MBacké ; Harry, Myriam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-13ef73073f5aaa6a89d9669a7ad7c3ea4be8877baf52b65bf00034107f96d2263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>An. coluzzii and An. arabiensis</topic><topic>An. gambiae</topic><topic>Animal genetics</topic><topic>Animals</topic><topic>Anopheles</topic><topic>Anopheles - drug effects</topic><topic>Anopheles - genetics</topic><topic>Anopheles gambiae</topic><topic>Aquatic insects</topic><topic>Assortative mating</topic><topic>Bias</topic><topic>Chromosomes</topic><topic>Control</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Gene Flow - drug effects</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic structure</topic><topic>Genetic variation</topic><topic>Genetic Variation - drug effects</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Human diseases</topic><topic>Human health and pathology</topic><topic>Hybridization, Genetic - drug effects</topic><topic>Hybrids</topic><topic>Inbreeding</topic><topic>Infectious diseases</topic><topic>Insecticide-Treated Bednets - utilization</topic><topic>Insecticides</topic><topic>Insecticides - pharmacology</topic><topic>Life Sciences</topic><topic>LLINs</topic><topic>Malaria</topic><topic>Mating</topic><topic>Microsatellite Repeats - drug effects</topic><topic>Microsatellites</topic><topic>Mosquito Control</topic><topic>Mosquitoes</topic><topic>Nets</topic><topic>Outdoors</topic><topic>Population genetics</topic><topic>Population number</topic><topic>Probability theory</topic><topic>Reproductive behaviour</topic><topic>Senegal</topic><topic>Sibling species</topic><topic>Species Specificity</topic><topic>Studies</topic><topic>Sympatric populations</topic><topic>Vector-borne diseases</topic><topic>Vectors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sougoufara, Seynabou</creatorcontrib><creatorcontrib>Sokhna, Cheikh</creatorcontrib><creatorcontrib>Diagne, Nafissatou</creatorcontrib><creatorcontrib>Doucouré, Souleymane</creatorcontrib><creatorcontrib>Sembène, Pape MBacké</creatorcontrib><creatorcontrib>Harry, Myriam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Malaria journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sougoufara, Seynabou</au><au>Sokhna, Cheikh</au><au>Diagne, Nafissatou</au><au>Doucouré, Souleymane</au><au>Sembène, Pape MBacké</au><au>Harry, Myriam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal</atitle><jtitle>Malaria journal</jtitle><addtitle>Malar J</addtitle><date>2017-08-15</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>337</spage><epage>337</epage><pages>337-337</pages><artnum>337</artnum><issn>1475-2875</issn><eissn>1475-2875</eissn><abstract>Mosquitoes belonging to the Anopheles gambiae complex are the main vectors of malaria in sub-Saharan Africa. Among these, An. gambiae, Anopheles coluzzii and Anopheles arabiensis are the most efficient vectors and are largely distributed in sympatric locations. However, these species present ecological and behavioural differences that impact their vectorial capacity and complicate vector-control efforts, mainly based on long-lasting insecticidal bed nets (LLINs) and indoor residual spraying (IRS). In this study, the genetic structure of these three species in a Senegalese village (Dielmo) was investigated using microsatellite data in samples collected in 2006 before implementation of LLINs, in 2008, when they were introduced, and in 2010, 2 years after the use of LLINs.
In this study 611 individuals were included, namely 136 An. coluzzii, 101 An. gambiae, 6 An. coluzzii/An. gambiae hybrids and 368 An. arabiensis. According to the species, the effect of the implementation of LLINs in Dielmo is differentiated. Populations of the sister species An. coluzzii and An. gambiae regularly experienced bottleneck events, but without significant inbreeding. The Fst values suggested in 2006 a breakdown of assortative mating resulting in hybrids, but the introduction of LLINs was followed by a decrease in the number of hybrids. This suggests a decrease in mating success of hybrids, ecological maladaptation, or a lesser probability of mating between species due to a decrease in An. coluzzii population size. By contrast, the introduction of LLINs has favoured the sibling species An. arabiensis. In this study, some spatial and temporal structuration between An. arabiensis populations were detected, especially in 2008, and the higher genetic diversity observed could result from a diversifying selection.
This work demonstrates the complexity of the malaria context and shows the need to study the genetic structure of Anopheles populations to evaluate the effectiveness of vector-control tools and successful management of malaria vector control.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28810861</pmid><doi>10.1186/s12936-017-1992-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0683-153X</orcidid><orcidid>https://orcid.org/0000-0003-4810-8232</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | An. coluzzii and An. arabiensis An. gambiae Animal genetics Animals Anopheles Anopheles - drug effects Anopheles - genetics Anopheles gambiae Aquatic insects Assortative mating Bias Chromosomes Control Deoxyribonucleic acid DNA Gene Flow - drug effects Genetic aspects Genetic diversity Genetic structure Genetic variation Genetic Variation - drug effects Genetics Health aspects Human diseases Human health and pathology Hybridization, Genetic - drug effects Hybrids Inbreeding Infectious diseases Insecticide-Treated Bednets - utilization Insecticides Insecticides - pharmacology Life Sciences LLINs Malaria Mating Microsatellite Repeats - drug effects Microsatellites Mosquito Control Mosquitoes Nets Outdoors Population genetics Population number Probability theory Reproductive behaviour Senegal Sibling species Species Specificity Studies Sympatric populations Vector-borne diseases Vectors |
title | The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A43%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20implementation%20of%20long-lasting%20insecticidal%20bed%20nets%20has%20differential%20effects%20on%20the%20genetic%20structure%20of%20the%20African%20malaria%20vectors%20in%20the%20Anopheles%20gambiae%20complex%20in%20Dielmo,%20Senegal&rft.jtitle=Malaria%20journal&rft.au=Sougoufara,%20Seynabou&rft.date=2017-08-15&rft.volume=16&rft.issue=1&rft.spage=337&rft.epage=337&rft.pages=337-337&rft.artnum=337&rft.issn=1475-2875&rft.eissn=1475-2875&rft_id=info:doi/10.1186/s12936-017-1992-8&rft_dat=%3Cgale_doaj_%3EA511283311%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c594t-13ef73073f5aaa6a89d9669a7ad7c3ea4be8877baf52b65bf00034107f96d2263%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2348266349&rft_id=info:pmid/28810861&rft_galeid=A511283311&rfr_iscdi=true |