Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high...

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Bibliographic Details
Published in:Pharmaceutics 2021-07, Vol.13 (7), p.999
Main Authors: Contardi, Marco, Lenzuni, Martina, Fiorentini, Fabrizio, Summa, Maria, Bertorelli, Rosalia, Suarato, Giulia, Athanassiou, Athanassia
Format: Article
Language:English
Subjects:
Acids
anti-bacterial
anti-inflammatory
anti-oxidants
Antimicrobial agents
Biosynthesis
Citrus fruits
Cosmetics
COVID-19
Dermatitis
Diabetes
Functional foods & nutraceuticals
hydroxycinnamic acids
Injuries
Metabolism
Packaging
Psoriasis
Review
Skin
skin care
skin disorders
Ulcers
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Summary:Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue' repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules' current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13070999