Cellular spelunking: exploring adipocyte caveolae

It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, as manifested by the numerous publications on the t...

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Bibliographic Details
Published in:Journal of lipid research 2007-10, Vol.48 (10), p.2103-2111
Main Authors: Pilch, Paul F., Souto, Ricardo P., Liu, Libin, Jedrychowski, Mark P., Berg, Eric A., Costello, Catherine E., Gygi, Steven P.
Format: Article
Language:English
Subjects:
Adipocytes - metabolism
Animals
Caveolae - metabolism
caveolin
Caveolins - metabolism
cavin
Cell Membrane - metabolism
fatty acid
Humans
Insulin - metabolism
Lipid Metabolism
Models, Biological
Phosphorylation
proteomics
Proteomics - methods
Rats
Signal Transduction
Tyrosine - metabolism
uptake
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Summary:It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, as manifested by the numerous publications on the topic that describe various, sometimes contradictory, caveolae functions. Here, we review the field from an “adipocentric” point of view and suggest that caveolae may have a function of particular use for the fat cell, namely the modulation of fatty acid flux across the plasma membrane. Other functions for adipocyte caveolae that have been postulated include participation in signal transduction and membrane trafficking pathways, and it will require further experimental scrutiny to resolve controversies surrounding these possible activities.
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.R700009-JLR200