Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

Glycoprotein nonmetastatic melanoma protein B (GPNMB) is involved in various cell functions such as cell adhesion, migration, proliferation, and differentiation. In this study, we set forth to determine the role of GPNMB in systemic sclerosis (SSc) fibroblasts. Dermal fibroblasts were isolated from...

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Published in:Frontiers in immunology 2022-02, Vol.13, p.814533-814533
Main Authors: Palisoc, Pamela J, Vaikutis, Leah, Gurrea-Rubio, Mikel, Model, Ellen N, O'mara, Morgan M, Ory, Sarah, Vichaikul, Sirapa, Khanna, Dinesh, Tsou, Pei-Suen, Sawalha, Amr H
Format: Article
Language:English
Subjects:
autoimmunity
dermal fibroblasts
Fibrosis
Glycoproteins
GPNMB
Humans
Immunology
Melanoma
Membrane Glycoproteins - genetics
Receptors, Fc
scleroderma
Scleroderma, Diffuse
Scleroderma, Localized
Scleroderma, Systemic - pathology
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Summary:Glycoprotein nonmetastatic melanoma protein B (GPNMB) is involved in various cell functions such as cell adhesion, migration, proliferation, and differentiation. In this study, we set forth to determine the role of GPNMB in systemic sclerosis (SSc) fibroblasts. Dermal fibroblasts were isolated from skin biopsies from healthy subjects and patients with diffuse cutaneous (dc)SSc. GPNMB was upregulated in dcSSc fibroblasts compared to normal fibroblasts, and correlated negatively with the modified Rodnan skin score. In addition, dcSSc fibroblasts secreted higher levels of soluble (s)GPNMB (147.4 ± 50.2 pg/ml vs. 84.8 ± 14.8 pg/ml, p
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.814533