Synthesis, Spectroscopic Characterization, Molecular Docking, and Evaluation of Antibacterial Potential of Transition Metal Complexes Obtained Using Triazole Chelating Ligand

Mononuclear chelates of Ni(II), Co(II), Fe(III), Cd(II), and Cu(II) derived from triazole novel tridentate ligands were prepared and characterized by different spectroscopic methods. The metal to ligand ratio was 1 : 2, which was revealed by elemental analysis. All the complexes were electrolytic in...

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Bibliographic Details
Published in:Journal of chemistry 2020, Vol.2020 (2020), p.1-12
Main Authors: Abd El Salam, Hayam A., Mohamed, Gehad G., Zayed, Ehab M., Al-Radadi, Najlaa S.
Format: Article
Language:English
Subjects:
Antibacterial agents
Biological activity
Chelates
Chelation
Chemical analysis
Chemical synthesis
Cobalt
Computer software industry
Coordination compounds
Copper
E coli
Ethanol
Experiments
Iron
Ligands
Molecular docking
Nickel
Solids
Thermal stability
Transition metal compounds
Triazoles
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Summary:Mononuclear chelates of Ni(II), Co(II), Fe(III), Cd(II), and Cu(II) derived from triazole novel tridentate ligands were prepared and characterized by different spectroscopic methods. The metal to ligand ratio was 1 : 2, which was revealed by elemental analysis. All the complexes were electrolytic in nature as suggested by the conductivity measurements. IR pointed out that the coordination of the triazole ligand toward the metal ions was carried out through N amino and S thiophenolic atoms. The complexes were found to have octahedral geometry, and their thermal stability was also studied. The XRD spectrum of Co(II) and Fe(III) complexes concluded their crystalline structure. The parent ligand and its chelates were investigated for antimicrobial potential. Bioassay of all triazole complexes showed increased activity as compared to that of the ligand. The complexes having Ni(II), Co(II), and Cu(II) ions as metal center exhibited superior antibacterial activity in opposition to Gram-positive (B. subtilis and S. pyogenes) and Gram-negative (E. coli and P. vulgaris) bacterium as compared to standard.
ISSN:2090-9063
2090-9071
DOI:10.1155/2020/1548641