Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals

A cooperative catalytic strategy of chiral iminium catalysis by regioselective activation of the C=C bond in enals and a transition metal promoting to open the 2-vinylcyclopropanes for highly regio- and enantioselective [3 + 2] cycloaddition reaction of 2-vinylcyclopropanes with α,β-unsaturated alde...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2016-06, Vol.12 (1), p.1340-1347
Main Authors: Zhu, Haipan, Du, Peile, Li, Jianjun, Liao, Ziyang, Liu, Guohua, Li, Hao, Wang, Wei
Format: Article
Language:English
Subjects:
[3 + 2] annulation
Chemistry
enals
Full Research Paper
synergistic catalysis
vinylcyclopropanes
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Summary:A cooperative catalytic strategy of chiral iminium catalysis by regioselective activation of the C=C bond in enals and a transition metal promoting to open the 2-vinylcyclopropanes for highly regio- and enantioselective [3 + 2] cycloaddition reaction of 2-vinylcyclopropanes with α,β-unsaturated aldehydes has been developed.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.12.127