Extracellular Vesicles-Based Cell-Cell Communication in Melanoma: New Perspectives in Diagnostics and Therapy

Extracellular vesicles (EVs) are a heterogeneous group of cell-secreted particles that carry cargo of functional biomolecules crucial for cell-to-cell communication with both physiological and pathophysiological consequences. In this review, we focus on evidence demonstrating that the EV-mediated cr...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (2), p.965
Main Authors: Kluszczynska, Katarzyna, Czyz, Malgorzata
Format: Article
Language:English
Subjects:
Angiogenesis
biomarker
Biomolecules
Biosynthesis
Cancer therapies
Cell Communication
Cell cycle
cell-cell communication
Communication
Crosstalk
Cyclin-dependent kinases
drug resistance
exosomes
Extracellular matrix
Extracellular vesicles
Extracellular Vesicles - pathology
Fibroblasts
Growth factors
Homeostasis
Humans
Immune system
Immunotherapy
Kinases
MEK inhibitors
Melanoma
Melanoma - diagnosis
Melanoma - pathology
Melanoma - therapy
Metastases
Metastasis
Neoplasms - pathology
Plasma
Protein Kinase Inhibitors
Proteins
Review
Stromal cells
Tumor Microenvironment - physiology
Vesicles
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Summary:Extracellular vesicles (EVs) are a heterogeneous group of cell-secreted particles that carry cargo of functional biomolecules crucial for cell-to-cell communication with both physiological and pathophysiological consequences. In this review, we focus on evidence demonstrating that the EV-mediated crosstalk between melanoma cells within tumor, between melanoma cells and immune and stromal cells, promotes immune evasion and influences all steps of melanoma development from local progression, pre-metastatic niche formation, to metastatic colonization of distant organs. We also discuss the role of EVs in the development of resistance to immunotherapy and therapy with BRAF /MEK inhibitors, and shortly summarize the recent advances on the potential applications of EVs in melanoma diagnostics and therapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24020965