Extraskeletal Ewing sarcoma of the parapharyngeal space with a unique translocation, t(19;22) (q13.4;q12.2)

Abstract Extraskeletal Ewing sarcomas of the parapharyngeal space are extremely rare. It has been documented that Ewing sarcomas are morphologically and molecularly indistinguishable regardless of the tissue of origin. Around 85% of Ewing sarcomas are associated with translocation t(11;22)(q24.1;12....

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Published in:Human pathology : case reports 2016-06, Vol.4 (C), p.38-41
Main Authors: Ramos-Rivera, Gloria, Adler, Esther, Ramesh, K.H, Schiff, Bradley, Suhrland, Mark, Khader, Samer
Format: Article
Language:English
Subjects:
Ewing sarcoma family of tumors
Extraskeletal Ewing sarcoma
Parapharyngeal space
Pathology
t(19
22)(q13.4
q12.2)
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container_title Human pathology : case reports
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creator Ramos-Rivera, Gloria
Adler, Esther
Ramesh, K.H
Schiff, Bradley
Suhrland, Mark
Khader, Samer
description Abstract Extraskeletal Ewing sarcomas of the parapharyngeal space are extremely rare. It has been documented that Ewing sarcomas are morphologically and molecularly indistinguishable regardless of the tissue of origin. Around 85% of Ewing sarcomas are associated with translocation t(11;22)(q24.1;12.2) generating the EWSR1–FLI1 fusion oncoprotein. We report a case of an extraskeletal Ewing sarcoma arising in the parapharyngeal space with a unique translocation: t(19; 22) (q13.4;q12.2). To our knowledge this is the first case of an extraskeletal Ewing sarcoma exhibiting this translocation.
doi_str_mv 10.1016/j.ehpc.2015.07.003
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subjects Ewing sarcoma family of tumors
Extraskeletal Ewing sarcoma
Parapharyngeal space
Pathology
t(19
22)(q13.4
q12.2)
title Extraskeletal Ewing sarcoma of the parapharyngeal space with a unique translocation, t(19;22) (q13.4;q12.2)
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