The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of C...

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Bibliographic Details
Published in:BMC cancer 2020-02, Vol.20 (1), p.106-106, Article 106
Main Authors: Zheng, Jian, Ye, Xiong, Liu, Yanan, Zhao, Yuxia, He, Mudan, Xiao, Hui
Format: Article
Language:English
Subjects:
Analysis
Antigens
Biomarkers
Breast cancer
Cancer patients
Cancer therapies
Carcinoembryonic antigen
CEA
Chromosomes
Circulating tumour cells
Copy number
Demographics
Diagnosis
Epithelial cells
Gender
Identification
Lung cancer
Lung nodules
Management
Medical examination
Non-small cell lung carcinoma
Patients
Solitary pulmonary nodules
Surgery
Thoracic surgery
Tumors
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Summary:Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of CTCs, carcinoembryonic antigen (CEA) and imaging findings to improve the sensitivity and specificity of diagnosis in patients with SPNs suspected of being lung cancer. For the serum biomarker assay, the concentration of CEA was measured by an automated electrochemiluminescence analyzer. CTCs were collected from 6 ml of blood by the SE i-FISH method, which detects the gene copy number in eight chromosomes and the tumour-associated antigen CK18. With a threshold of 6 CTC units, the method showed a sensitivity of 67.1% and a specificity of 56.5% in the diagnosis of NSCLC, especially in the upper lobe, in which the diagnostic strength was the highest (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-6524-1