High expressions of BCL6 and Lewis y antigen are correlated with high tumor burden and poor prognosis in epithelial ovarian cancer

Aberrant regulation of BCL6 plays crucial oncogenic roles in various malignant tumors; howbeit, the function of BCL6 in tumorigenesis of ovarian cancer remains unclear. The aim of this study is to investigate the role of BCL6 in ovarian cancer. The methods of immunohistochemical staining, quantitati...

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Bibliographic Details
Published in:Tumor biology 2017-07, Vol.39 (7), p.1010428317711655-1010428317711655
Main Authors: Zhu, Liancheng, Feng, Huilin, Jin, Shan, Tan, Mingzi, Gao, Song, Zhuang, Huiyu, Hu, Zhenhua, Wang, Huimin, Song, Zuofei, Lin, Bei
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Antigens
Apoptosis
Authorship
Autophagy
Bcl-6 protein
Breast cancer
Cancer therapies
Carcinoma, Ovarian Epithelial
Cell cycle
Cell growth
Disease-Free Survival
Drug resistance
Drug Resistance, Neoplasm - genetics
Female
Gadd45A protein
Gene expression
Gene Expression Regulation, Neoplastic
Genomes
Gynecology
Health surveillance
Humans
Lewis Blood-Group System - biosynthesis
Lewis Y antigen
Lymph nodes
Lymphatic Metastasis
Lymphoma
Medical prognosis
Metastases
Metastasis
Middle Aged
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Neoplasms, Glandular and Epithelial - genetics
Neoplasms, Glandular and Epithelial - pathology
Obstetrics
Ovarian cancer
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Patients
Peroxisome proliferator-activated receptors
Polymerase chain reaction
Prognosis
Proto-Oncogene Proteins c-bcl-6 - biosynthesis
Stat1 protein
Survival
Tumor Burden - genetics
Tumorigenesis
Tumors
Young Adult
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Summary:Aberrant regulation of BCL6 plays crucial oncogenic roles in various malignant tumors; howbeit, the function of BCL6 in tumorigenesis of ovarian cancer remains unclear. The aim of this study is to investigate the role of BCL6 in ovarian cancer. The methods of immunohistochemical staining, quantitative real-time polymerase chain reaction, immunocytochemical staining, and gene expression profile enrichment analysis were performed to identify the possible role of BCL6 in ovarian cancer. We observed that the expression of BCL6 was significantly higher in ovarian cancer tissues and correlated with higher tumor burden including advanced International Federation of Gynecology and Obstetrics stages, poor differentiation, Type II ovarian cancer, the presence of >1 cm residual tumor size, and appearance of recurrence or death (all p 1 cm, as well as high expressions of BCL6 and Lewis y antigen were independent factors of worse progression-free survival and overall survival (all p 
ISSN:1010-4283
1423-0380
DOI:10.1177/1010428317711655