Genetic polymorphism of HLA-DRB1 alleles in Mexican mestizo patients with abdominal aortic aneurysms

• Published in: BMC medical genetics 2019-06, Vol.20 (1), p.102-102, Article 102
• Main Authors: Anaya-Ayala, Javier E, Hernandez-Doño, Susana, Escamilla-Tilch, Monica, Marquez-Garcia, Jose, Hernandez-Sotelo, Kemberly, Lozano-Corona, Rodrigo, Ruiz-Gomez, Daniela, Granados, Julio, Hinojosa, Carlos A
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal aortic aneurysm; Abdominal aortic aneurysms; Age; Aged; Alleles; Aneurysm; Aneurysms; Antigens; Aortic Aneurysm, Abdominal - diagnosis; Aortic Aneurysm, Abdominal - ethnology; Aortic Aneurysm, Abdominal - genetics; Aortic aneurysms; Arteriosclerosis; Autoimmune diseases; Autoimmunity; Case-Control Studies; Chronic obstructive pulmonary disease; Confidence intervals; Coronary vessels; Development and progression; Diagnosis; Disease susceptibility; Drb1 protein; Ethnic Groups - genetics; Ethnicity; Etiology; Etiology (Medicine); Families & family life; Female; Gender; Gene Frequency; Gene polymorphism; Genealogy; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genetic risk; Genetic screening; Genetic testing; Genetics; Health screening; Histocompatibility antigen HLA; HLA antigens; HLA-DRB1; HLA-DRB1 Chains - genetics; Humans; Male; Males; Medical imaging; Mexican population; Mexico; Middle Aged; Minority & ethnic groups; Native North Americans; Oligonucleotides; Pathogenesis; Polymorphism; Polymorphism, Genetic; Population; Population genetics; Racially mixed people; Risk factors; Smoking; Software; Studies; Susceptibility; Systematic review; Tissue typing; Tomography; Ultrasound
• ISSN: 1471-2350; 1471-2350
• DOI: 10.1186/s12881-019-0833-8

Multiple factors are implicated in the etiology and pathogenesis of Abdominal Aortic Aneurysms (AAA). Available literature of genetic studies has previously suggested the possible roles of autoimmunity, genetic predisposition and ethnic susceptibility. Due to the association with autoimmune diseases and proven application in population genetics, we aimed to investigate alleles of the Class II Human Leukocyte Antigens (HLA-DRB1) in the Mexican Mestizo population with aortic aneurysms and determine possible associations with susceptibility. We performed a case Control Study; the HLA molecular typing was completed for DRB1 loci by LabType Sequence-Specific Oligonucleotide (SSO) SSO-OneLambda kit (Applied Biosystems; Thermo Fisher Scientific. Inc.) in the studied individuals. Allele frequencies (af) were determined, associations were assessed by chi square or fisher exact tests at significance level (