The Role of Natural Low Molecular Weight Dicarbonyls in Atherogenesis and Diabetogenesis

• Published in: Reviews in cardiovascular medicine 2024-08, Vol.25 (8), p.295
• Main Authors: Lankin, Vadim Z, Tikhaze, Alla K, Sharapov, Mars G, Konovalova, Galina G
• Format: Article
• Language: English
• Subjects: antioxidant enzymes; apoptosis; atherosclerosis; carbonyl stress; diabetes; endotheliocites; free radical oxidation (fro); glutathione peroxidase (gsh-px); glyoxal; lectin like oxidized low density lipoprotein receptor 1 (lox-1); lipoperoxides (looh); low density lipoproteins (ldl); low molecular weight dicarbonyls; malondialdehyde (mda); mda-modified ldl (mda-ldl); methylglyoxal; nadph oxidase 1 (nox-1); oxidative stress; oxidized (looh contained) ldl (looh-ldl); peroxiredoxines; reactive carbonyl species (rcs); reactive oxygen species (ros); Review; superoxide anion radical (o2•-); superoxide dismutase (sod)
• ISSN: 1530-6550; 2153-8174; 2153-8174
• DOI: 10.31083/j.rcm2508295

This review summarises the data from long-term experimental studies and literature data on the role of oxidatively modified low-density lipoproteins (LDL) in atherogenesis and diabetogenesis. It was shown that not "oxidized" (lipoperoxide-containing) LDL, but dicarbonyl-modified LDL are atherogenic (actively captured by cultured macrophages with the help of scavenger receptors), and also cause expression of lectin like oxidized low density lipoprotein receptor 1 ( ) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 ( ) genes in endotheliocytes, which stimulate apoptosis and endothelial dysfunction. The obtained data allowed us to justify new approaches to pharmacotherapy of atherosclerosis and diabetes mellitus.