Bioinformatics analysis of potential essential genes that response to the high intraocular pressure on astrocyte due to glaucoma

AIM: To study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma.METHODS: We used glaucoma related microarray data in public database [Gene Expression Omnibus(GEO)] to explore the potential gene expression changes as well as corresp...

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Bibliographic Details
Published in:International journal of ophthalmology 2015-04, Vol.8 (2), p.395-398
Main Authors: Yang, Yang, Duan, Jing-Zhu, Di, Yu, Gui, Dong-Mei, Gao, Dian-Wen
Format: Article
Language:English
Subjects:
astrocytes
glaucoma
high
high intraocular pressure
Informatics Research
intraocular
microarray
pressure
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Summary:AIM: To study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma.METHODS: We used glaucoma related microarray data in public database [Gene Expression Omnibus(GEO)] to explore the potential gene expression changes as well as correspondent biological process alterations due to increased pressure in astrocytes during glaucoma development.RESULTS: A total of six genes were identified to be related with pressure increasing. Through the annotation and network analysis, we found these genes might be involved in cell morphological remodeling, angiogenesis,mismatch repair.CONCLUSION: Increasing pressure in glaucoma on astrocytes might cause gene expression alterations,which might induce some cellular responses changes.
ISSN:2222-3959
2227-4898
DOI:10.3980/j.issn.2222-3959.2015.02.32