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Primary orthostatic tremor and orthostatic tremor‐plus in dogs: 60 cases (2003‐2020)
Background Orthostatic tremor (OT) is a rare movement disorder characterized by high‐frequency (>12 Hz) involuntary, rhythmic, sinusoidal movements affecting predominantly the limbs while standing. Objective To describe the signalment, presenting complaints, phenotype, diagnostic findings, treatm...
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Published in: | Journal of veterinary internal medicine 2022-01, Vol.36 (1), p.179-189 |
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Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Orthostatic tremor (OT) is a rare movement disorder characterized by high‐frequency (>12 Hz) involuntary, rhythmic, sinusoidal movements affecting predominantly the limbs while standing.
Objective
To describe the signalment, presenting complaints, phenotype, diagnostic findings, treatment, and outcome of a large sample of dogs with OT.
Animals
Sixty dogs diagnosed with OT based on conscious electromyography.
Methods
Multicenter retrospective case series study. Dogs were included if they had a conscious electromyography consistent with muscle discharge frequency >12 Hz while standing.
Results
Fifty‐three cases were diagnosed with primary OT (POT). Giant breed dogs represented most cases (83%; 44/53). Most dogs (79%; 42/53) were younger than 2 years of age at onset of signs, except for Retrievers which were all older than 3.5 years of age. The most common presenting complaints were pelvic limb tremors while standing (85%; 45/53) and difficulty when rising or sitting down (45%; 24/53). Improvement of clinical signs occurred in most dogs (85%; 45/53) treated medically with phenobarbital, primidone, gabapentin, pregabalin or clonazepam, but it was mostly partial rather than complete. Orthostatic tremor‐plus was seen in 7 dogs that had concurrent neurological diseases.
Conclusions and Clinical Importance
Primary OT is a progressive disease of young, purebred, giant/large‐breed dogs, which appears to begin later in life in Retrievers. Primary OT apparently responds partially to medications. Orthostatic tremor‐plus exists in dogs and can be concomitant or associated with other neurological diseases. |
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ISSN: | 0891-6640 1939-1676 |
DOI: | 10.1111/jvim.16328 |