Fulminant hepatic failure after repeated exposure to isoflurane

Inhalational agents are used routinely for maintenance of anaesthesia. Post anaesthesia hepatic failure has been documented following exposure to halothane. However, there are very few reports of such complications following isoflurane anaesthesia. A 6-year-old child developed fulminant hepatic fail...

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Bibliographic Details
Published in:Indian journal of anaesthesia 2011-05, Vol.55 (3), p.290-292
Main Authors: Kusuma, Halemani R, Venkataramana, Neelam K, Rao, Shailesh Av, Naik, Arun L, Gangadhara, Ds, Venkatesh, Keshavan H
Format: Article
Language:English
Subjects:
Anesthesia
Care and treatment
Case Report
Case studies
Children
Complications and side effects
Diagnosis
fulminant
hepatic failure
Isoflurane
Liver
Liver failure
Neurosurgery
Side effects
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Summary:Inhalational agents are used routinely for maintenance of anaesthesia. Post anaesthesia hepatic failure has been documented following exposure to halothane. However, there are very few reports of such complications following isoflurane anaesthesia. A 6-year-old child developed fulminant hepatic failure 2 days following craniotomy under general anaesthesia. There was no evidence of viral, autoimmune, or metabolic causes of hepatitis. No other medications known to cause hepatitis, except low dose paracetamol, were administered. The clinical and histological picture of our case is similar to that of halothane hepatitis, which has a significant mortality rate. We report this as a possible fulminant hepatic failure resulting from exposure to isoflurane anaesthesia.
ISSN:0019-5049
0976-2817
DOI:10.4103/0019-5049.82696