Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers

B cells are well known as key mediators of humoral immune responses the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect...

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Bibliographic Details
Published in:Frontiers in immunology 2021-11, Vol.12, p.765044-765044
Main Authors: Zhong, Ziwen, Nan, Ke, Weng, Meilin, Yue, Ying, Zhou, Wenchang, Wang, Zhiqiang, Chu, Yiwei, Liu, Ronghua, Miao, Changhong
Format: Article
Language:English
Subjects:
B cells
B-Lymphocytes - immunology
class switching
Humans
immunoglobulin A
Immunoglobulin A - immunology
Immunology
Neoplasms - immunology
plasma cells
tumor immunity
Tumor Microenvironment - immunology
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Summary:B cells are well known as key mediators of humoral immune responses the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.765044