Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation"

In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science...

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Bibliographic Details
Published in:Particle and fibre toxicology 2020-07, Vol.17 (1), p.33-3, Article 33
Main Authors: Driscoll, Kevin E, Borm, Paul A, Chaudhuri, Ishrat, Levy, Len, Yong, Mei, Warheit, David, McCunney, Robert, Oberdörster, Günter
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Blue collar workers
Carbon black
Carcinogens
Dust
Epidemiology
Health risks
Inhalation
Letter to the Editor
Lung
Lung cancer
Lung Neoplasms
Mortality
Nanomaterials
Nanotechnology
Rats
Respiration
Respiratory diseases
Rodents
Studies
Titanium
Toxicology
Citations: Items that this one cites
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Summary:In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the science is recounted accurately it does not support Saber et al's statements and conclusions.
ISSN:1743-8977
1743-8977
DOI:10.1186/s12989-020-00365-z