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Giardia duodenalis Colonization Slightly Affects Gut Microbiota and Hematological Parameters in Clinically Healthy Dogs
( ) is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs ( = 31), naturally infected or not by . Gut microbiota and the hematological, biochemical, and f...
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| Published in: | Animals (Basel) 2023-03, Vol.13 (6), p.958 |
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| Main Authors: | , , , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c476t-609367aa97dc041a4e15df26a3579de8250e7133631d63ec9212994e877dced33 |
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| container_start_page | 958 |
| container_title | Animals (Basel) |
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| creator | Peruzzo, Arianna Vascellari, Marta Massaro, Andrea Mancin, Marzia Stefani, Annalisa Orsini, Massimiliano Danesi, Patrizia Petrin, Sara Carminato, Antonio Santoro, Michele Matteo Speranza, Roberto Losasso, Carmen Capelli, Gioia |
| description | (
) is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs (
= 31), naturally infected or not by
. Gut microbiota and the hematological, biochemical, and fecal parameters related to intestinal function were investigated.
infection was associated with a significant shift of beta diversity, showing a relevant reduction of Gammaproteobacteria and an increase of Fusobacteria in male-positive dogs if compared with negatives. A significant imbalance of different bacterial taxa, with particular reference to the
,
,
, and
orders, was observed, with the first two being higher in
-positive dogs.
-positive males displayed significantly higher values of cCRP than negative males as well as positive females, supporting the presence of a pro-inflammatory state. Taken together, these results indicate that the presence of
does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease. Thus treatments against
should be considered with caution in asymptomatic subjects. |
| doi_str_mv | 10.3390/ani13060958 |
| format | article |
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) is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs (
= 31), naturally infected or not by
. Gut microbiota and the hematological, biochemical, and fecal parameters related to intestinal function were investigated.
infection was associated with a significant shift of beta diversity, showing a relevant reduction of Gammaproteobacteria and an increase of Fusobacteria in male-positive dogs if compared with negatives. A significant imbalance of different bacterial taxa, with particular reference to the
,
,
, and
orders, was observed, with the first two being higher in
-positive dogs.
-positive males displayed significantly higher values of cCRP than negative males as well as positive females, supporting the presence of a pro-inflammatory state. Taken together, these results indicate that the presence of
does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease. Thus treatments against
should be considered with caution in asymptomatic subjects.</description><identifier>ISSN: 2076-2615</identifier><identifier>EISSN: 2076-2615</identifier><identifier>DOI: 10.3390/ani13060958</identifier><identifier>PMID: 36978500</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antiparasitic agents ; Asymptomatic ; Automation ; Blood ; Colonization ; Cysts ; Diarrhea ; Digestive system ; Dogs ; Domestic animals ; Feces ; Giardia ; Giardia duodenalis ; gut ; Hematology ; Immunoassay ; Inflammation ; Intestinal microflora ; Intestine ; Investigations ; Lipid metabolism ; Lipids ; Microbiota ; Microorganisms ; Parasites ; Proteins ; Software ; Statistical analysis</subject><ispartof>Animals (Basel), 2023-03, Vol.13 (6), p.958</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-609367aa97dc041a4e15df26a3579de8250e7133631d63ec9212994e877dced33</citedby><cites>FETCH-LOGICAL-c476t-609367aa97dc041a4e15df26a3579de8250e7133631d63ec9212994e877dced33</cites><orcidid>0000-0002-6738-2125 ; 0000-0001-6912-2266 ; 0000-0001-8481-0171 ; 0000-0002-4537-4386 ; 0000-0002-8071-0285</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2791562503/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2791562503?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36978500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peruzzo, Arianna</creatorcontrib><creatorcontrib>Vascellari, Marta</creatorcontrib><creatorcontrib>Massaro, Andrea</creatorcontrib><creatorcontrib>Mancin, Marzia</creatorcontrib><creatorcontrib>Stefani, Annalisa</creatorcontrib><creatorcontrib>Orsini, Massimiliano</creatorcontrib><creatorcontrib>Danesi, Patrizia</creatorcontrib><creatorcontrib>Petrin, Sara</creatorcontrib><creatorcontrib>Carminato, Antonio</creatorcontrib><creatorcontrib>Santoro, Michele Matteo</creatorcontrib><creatorcontrib>Speranza, Roberto</creatorcontrib><creatorcontrib>Losasso, Carmen</creatorcontrib><creatorcontrib>Capelli, Gioia</creatorcontrib><title>Giardia duodenalis Colonization Slightly Affects Gut Microbiota and Hematological Parameters in Clinically Healthy Dogs</title><title>Animals (Basel)</title><addtitle>Animals (Basel)</addtitle><description>(
) is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs (
= 31), naturally infected or not by
. Gut microbiota and the hematological, biochemical, and fecal parameters related to intestinal function were investigated.
infection was associated with a significant shift of beta diversity, showing a relevant reduction of Gammaproteobacteria and an increase of Fusobacteria in male-positive dogs if compared with negatives. A significant imbalance of different bacterial taxa, with particular reference to the
,
,
, and
orders, was observed, with the first two being higher in
-positive dogs.
-positive males displayed significantly higher values of cCRP than negative males as well as positive females, supporting the presence of a pro-inflammatory state. Taken together, these results indicate that the presence of
does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease. Thus treatments against
should be considered with caution in asymptomatic subjects.</description><subject>Animals</subject><subject>Antiparasitic agents</subject><subject>Asymptomatic</subject><subject>Automation</subject><subject>Blood</subject><subject>Colonization</subject><subject>Cysts</subject><subject>Diarrhea</subject><subject>Digestive system</subject><subject>Dogs</subject><subject>Domestic animals</subject><subject>Feces</subject><subject>Giardia</subject><subject>Giardia duodenalis</subject><subject>gut</subject><subject>Hematology</subject><subject>Immunoassay</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Investigations</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Parasites</subject><subject>Proteins</subject><subject>Software</subject><subject>Statistical analysis</subject><issn>2076-2615</issn><issn>2076-2615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkt1rFDEUxQdRbFn75LsEfBFkNZl8zTxJWXW3UFFQn8OdJDObJTOpSaay_vVmu7VszUvCzbk_7uGeqnpJ8DtKW_weJkcoFrjlzZPqvMZSLGtB-NOT91l1kdIOlyM5JZw8r86oaGXDMT6vfq8dROMAmTkYO4F3Ca2CD5P7A9mFCX33bthmv0eXfW91Tmg9Z_TF6Rg6FzIgmAza2BFyaRqcBo--QYTRZhsTchNaeTcdyoWwseDzdo8-hiG9qJ714JO9uL8X1c_Pn36sNsvrr-ur1eX1UjMp8rIYo0ICtNJozAgwS7jpawGUy9bYpubYSkKpoMQIanVbk7ptmW1kabCG0kV1deSaADt1E90Ica8COHVXCHFQELPT3qqGWd6DqYlogRGqO91ZzShlnWCmM7ywPhxZN3M32sKfcgT_CPr4Z3JbNYRbRTBmTGBZCG_uCTH8mm3KanRJW-9hsmFOqpZtcVTj4mdRvf5PugtzLAu6UxEuivBg7-1RVfaRUrT9wzQEq0NA1ElAivrVqYEH7b840L8lbLcP</recordid><startdate>20230307</startdate><enddate>20230307</enddate><creator>Peruzzo, Arianna</creator><creator>Vascellari, Marta</creator><creator>Massaro, Andrea</creator><creator>Mancin, Marzia</creator><creator>Stefani, Annalisa</creator><creator>Orsini, Massimiliano</creator><creator>Danesi, Patrizia</creator><creator>Petrin, Sara</creator><creator>Carminato, Antonio</creator><creator>Santoro, Michele Matteo</creator><creator>Speranza, Roberto</creator><creator>Losasso, Carmen</creator><creator>Capelli, Gioia</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6738-2125</orcidid><orcidid>https://orcid.org/0000-0001-6912-2266</orcidid><orcidid>https://orcid.org/0000-0001-8481-0171</orcidid><orcidid>https://orcid.org/0000-0002-4537-4386</orcidid><orcidid>https://orcid.org/0000-0002-8071-0285</orcidid></search><sort><creationdate>20230307</creationdate><title>Giardia duodenalis Colonization Slightly Affects Gut Microbiota and Hematological Parameters in Clinically Healthy Dogs</title><author>Peruzzo, Arianna ; 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) is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs (
= 31), naturally infected or not by
. Gut microbiota and the hematological, biochemical, and fecal parameters related to intestinal function were investigated.
infection was associated with a significant shift of beta diversity, showing a relevant reduction of Gammaproteobacteria and an increase of Fusobacteria in male-positive dogs if compared with negatives. A significant imbalance of different bacterial taxa, with particular reference to the
,
,
, and
orders, was observed, with the first two being higher in
-positive dogs.
-positive males displayed significantly higher values of cCRP than negative males as well as positive females, supporting the presence of a pro-inflammatory state. Taken together, these results indicate that the presence of
does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease. Thus treatments against
should be considered with caution in asymptomatic subjects.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36978500</pmid><doi>10.3390/ani13060958</doi><orcidid>https://orcid.org/0000-0002-6738-2125</orcidid><orcidid>https://orcid.org/0000-0001-6912-2266</orcidid><orcidid>https://orcid.org/0000-0001-8481-0171</orcidid><orcidid>https://orcid.org/0000-0002-4537-4386</orcidid><orcidid>https://orcid.org/0000-0002-8071-0285</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Animals (Basel), 2023-03, Vol.13 (6), p.958 |
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| language | eng |
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| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Animals Antiparasitic agents Asymptomatic Automation Blood Colonization Cysts Diarrhea Digestive system Dogs Domestic animals Feces Giardia Giardia duodenalis gut Hematology Immunoassay Inflammation Intestinal microflora Intestine Investigations Lipid metabolism Lipids Microbiota Microorganisms Parasites Proteins Software Statistical analysis |
| title | Giardia duodenalis Colonization Slightly Affects Gut Microbiota and Hematological Parameters in Clinically Healthy Dogs |
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