Role of secreted frizzled-related protein 4 in prediabetes and type 2 diabetes: a cross sectional study

Type 2 diabetes (T2D) has become an epidemic. Delays in diagnosis and as a consequent late treatment has resulted in high prevalence of complications and mortality. Secreted frizzled-related protein 4 (SFRP4), has been recently identified as a potential early biomarker of T2D related to obesity, due...

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Bibliographic Details
Published in:BMC endocrine disorders 2024-06, Vol.24 (1), p.78-10
Main Authors: Sánchez-Pozos, Katy, Granados-Silvestre, M A, Nieto-Velázquez, N G, Mejía-Blanquel, María Alicia, Galicia-Martínez, Natsyelli, Mandujano-Cerón, Jessica, Jaimes-Santoyo, Joel, Ortiz-López, María Guadalupe
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissues
Adult
Analysis
Biomarker
Biomarkers
Biomarkers - blood
Body fat
Body mass index
Case-Control Studies
Cholesterol
Cross-Sectional Studies
Cytokines
Development and progression
Dextrose
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Disease prevention
Enzyme-linked immunosorbent assay
Ethylenediaminetetraacetic acid
Female
Flow cytometry
Frizzled protein
Frizzled-related protein
Genetic diversity
Genotyping
Glucose
Glucose metabolism
Glycosylated hemoglobin
Health aspects
High density lipoprotein
Homeostasis
Hospitals
Humans
IL-1β
Illinois
Inflammation
Insulin
Insulin resistance
Interleukin 10
Interleukin 6
Interleukin 8
Lipoproteins
Male
Metabolic disorders
Mexico
Middle Aged
Mortality
Obesity
Physiological aspects
Prediabetes
Prediabetic state
Prediabetic State - blood
Prediabetic State - diagnosis
Prediabetic State - epidemiology
Prognosis
Proteins
Proto-Oncogene Proteins
SFRP4
insulin resistance
Software
Statistical power
Type 2 diabetes
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Summary:Type 2 diabetes (T2D) has become an epidemic. Delays in diagnosis and as a consequent late treatment has resulted in high prevalence of complications and mortality. Secreted frizzled-related protein 4 (SFRP4), has been recently identified as a potential early biomarker of T2D related to obesity, due to its association with low grade inflammation in adipose tissue and impaired glucose metabolism. We aimed to evaluate the role of SFRP4 in prediabetes and T2D in a Mexican population. This was a cross-sectional study that included 80 subjects with T2D, 50 subjects with prediabetes and 50 healthy individuals. Fasting SFRP4 and insulin concentrations were measured by ELISA. Human serum IL-10, IL-6, IL-1β and IL-8 levels were quantified by flow cytometry. Genotyping was performed by TaqMan® probes. Prediabetes and T2D patients had significantly higher SFRP4 levels than controls (P 
ISSN:1472-6823
1472-6823
DOI:10.1186/s12902-024-01613-5