Features of Cytokine Storm Identified by Distinguishing Clinical Manifestations in COVID-19

Coronavirus disease 2019 (COVID-19) is caused by a new coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently spreading all over the world. In this paper, we developed a practical model for identifying the features of cytokine storm, which is common in acut...

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Bibliographic Details
Published in:Frontiers in public health 2021-05, Vol.9, p.671788-671788
Main Authors: Shen, Wei-Xi, Luo, Rong-Cheng, Wang, Jing-Quan, Chen, Zhe-Sheng
Format: Article
Language:English
Subjects:
clinical manifestation
coronavirus disease 2019 (COVID-19)
Coronavirus Infections
COVID-19 Drug Treatment
Cytokine Release Syndrome
cytokine storm
Humans
pathogenesis
Public Health
SARS-CoV-2
transforming growth factor-β (TGF-β)
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Summary:Coronavirus disease 2019 (COVID-19) is caused by a new coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently spreading all over the world. In this paper, we developed a practical model for identifying the features of cytokine storm, which is common in acute infectious diseases and harmful manifestation of COVID-19, by distinguishing major and minor clinical events. This model is particularly suitable for identifying febrile and infectious diseases like COVID-19. Based on this model, features of cytokine storm and pathogenesis of COVID-19 have been proposed to be a consequence of the disequilibrated cytokine network resulting from increased biological activity of transforming growth factor-β (TGF-β), which induces certain clinical manifestations such as fatigue, fever, dry cough, pneumonia, abatement and losing of olfactory, and taste senses in some patients. Research and clarification of the pathogenesis of COVID-19 will contribute to precision treatment. Various anti-TGF-β therapies may be explored as potential COVID-19 treatment. This novel model will be helpful in reducing the widespread mortality of COVID-19.
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2021.671788