Beneficial effects of Spirogyra Neglecta Extract on antioxidant and anti-inflammatory factors in streptozotocin-induced diabetic rats

This study was conducted to evaluate the effects of oral supplementation of Spirogyra algae on oxidative damages and inflammatory responses in streptozotocin (STZ)-induced diabetic rats. Methods Diabetes was induced by administration of 55 mg/kg of streptozotocin. A total of sixty-four rats were div...

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Published in:Biomolecular concepts 2018-12, Vol.9 (1), p.184-189
Main Authors: Mesbahzadeh, Behzad, Rajaei, Seyed Ali, Tarahomi, Parnia, Seyedinia, Seyed Ali, Rahmani, Mehrnoush, Rezamohamadi, Fatemeh, Kakar, Muhammad Azam, Moradi-Kor, Nasroallah
Format: Article
Language:English
Subjects:
Algae
Antioxidant status
Antioxidants
C-reactive protein
Cholesterol
Diabetes
Diabetes mellitus
Dietary supplements
Glutathione
Inflammation
Inflammatory parameters
Insulin
Interleukin 6
Malondialdehyde
Oxidative stress
Rat
Rodents
Serum levels
Spirogyra
Streptozocin
Triglycerides
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:This study was conducted to evaluate the effects of oral supplementation of Spirogyra algae on oxidative damages and inflammatory responses in streptozotocin (STZ)-induced diabetic rats. Methods Diabetes was induced by administration of 55 mg/kg of streptozotocin. A total of sixty-four rats were divided into eight groups of eight rats each as follows:1) non-diabetic control; 2, 3, and 4) non-diabetic rats treated with 15, 30, and 45 mg of Spirogyra algae/kg/d; 5) control diabetic; and 6, 7, and 8) diabetic rats treated with 15, 30, and 45 mg of Spirogyra algae extract. At the end of the trial, the serum concentrations of glucose, interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS), C-reactive protein (CRP), insulin, triglycerides, and cholesterol were examined by specified procedures. Results Our findings indicated that the administration of STZ significantly increased the serum concentrations of glucose, triglycerides, cholesterol, CRP, IL-6, TNF-a, and MDA and decreased the serum levels of GSH and TAS (P Spirogyra alleviated adverse effects of diabetes on oxidative stress and inflammatory factors in diabetic rats (P Conclusion It can be stated that Spirogyra algae extract can be used for treatment of diabetes likely due to prevention of oxidative stress and alleviation of inflammation in the rat model.
ISSN:1868-5021
1868-5021
1868-503X
DOI:10.1515/bmc-2018-0015