Application of cardiovascular interventions to decrease blood loss during hepatectomy: a systematic review and meta-analysis

Perioperative bleeding and allogeneic blood transfusion are generally thought to affect the outcomes of patients. This meta-analysis aimed to determine the benefits and risks of several cardiovascular interventions in patients undergoing hepatectomy. In this systematic review and meta-analysis, rand...

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Bibliographic Details
Published in:BMC anesthesiology 2023-03, Vol.23 (1), p.89-16, Article 89
Main Authors: Ye, Hui, Wu, Hanghang, Li, Bin, Zuo, Pengfei, Chen, Chaobo
Format: Article
Language:English
Subjects:
Adult
Bleeding
Blood donors
Blood loss
Blood Loss, Surgical - prevention & control
Blood Transfusion
Blood transfusions
Cardiac patients
Cardiovascular interventions
Clinical trials
Comparative analysis
Complications
Health aspects
Hepatectomy
Hepatectomy - adverse effects
Humans
Liver
Meta-analysis
Mortality
Postoperative
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Postoperative Complications - prevention & control
Preoperative Care
Recovery (Medical)
Transfusion
Venous pressure
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Summary:Perioperative bleeding and allogeneic blood transfusion are generally thought to affect the outcomes of patients. This meta-analysis aimed to determine the benefits and risks of several cardiovascular interventions in patients undergoing hepatectomy. In this systematic review and meta-analysis, randomised controlled trials (RCTs) were searched in the Cochrane Library, Medline, Embase, and Web of Science to February 02, 2023. RCTs focused on cardiovascular interventions aimed at reducing blood loss or blood transfusion requirements during hepatectomy were included. The primary outcomes were perioperative blood loss amount, number of patients requiring allogeneic blood transfusion and overall occurrence of postoperative complications. The secondary outcomes were operating time, perioperative mortality rate, postoperative liver and kidney function and length of hospital stay. Seventeen RCTs were included in the analysis. A total of 841 patients who underwent hepatectomy in 10 trials were included in the comparative analysis between low central venous pressure (CVP) and control groups. The forest plots showed a low operative bleeding volume [(mean difference (MD): -409.75 mL, 95% confidence intervals (CI) -616.56 to -202.94, P 
ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-023-02042-y