Germline stem cells in human

The germline cells are essential for the propagation of human beings, thus essential for the survival of mankind. The germline stem cells, as a unique cell type, generate various states of germ stem cells and then differentiate into specialized cells, spermatozoa and ova, for producing offspring, wh...

Full description

Saved in:
Bibliographic Details
Published in:Signal transduction and targeted therapy 2022-10, Vol.7 (1), p.345-345, Article 345
Main Authors: Cheng, Hanhua, Shang, Dantong, Zhou, Rongjia
Format: Article
Language:English
Subjects:
631/532/2064
631/80
692/4017
Cancer Research
Cell Biology
Cell differentiation
Embryo cells
Embryogenesis
Germ cells
Gonads
Infertility
Internal Medicine
Medicine
Medicine & Public Health
Meiosis
Molecular modelling
Oncology
Oocytes
Ova
Pathology
Pluripotency
Puberty
Review
Review Article
Sperm
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The germline cells are essential for the propagation of human beings, thus essential for the survival of mankind. The germline stem cells, as a unique cell type, generate various states of germ stem cells and then differentiate into specialized cells, spermatozoa and ova, for producing offspring, while self-renew to generate more stem cells. Abnormal development of germline stem cells often causes severe diseases in humans, including infertility and cancer. Primordial germ cells (PGCs) first emerge during early embryonic development, migrate into the gentile ridge, and then join in the formation of gonads. In males, they differentiate into spermatogonial stem cells, which give rise to spermatozoa via meiosis from the onset of puberty, while in females, the female germline stem cells (FGSCs) retain stemness in the ovary and initiate meiosis to generate oocytes. Primordial germ cell-like cells (PGCLCs) can be induced in vitro from embryonic stem cells or induced pluripotent stem cells. In this review, we focus on current advances in these embryonic and adult germline stem cells, and the induced PGCLCs in humans, provide an overview of molecular mechanisms underlying the development and differentiation of the germline stem cells and outline their physiological functions, pathological implications, and clinical applications.
ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-022-01197-3