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Interindividual Variability in Fat Mass Response to a 1-Year Randomized Controlled Trial With Different Exercise Intensities in Type 2 Diabetes: Implications on Glycemic Control and Vascular Function
Purpose : Little is known about the interindividual variability in fat mass (FM) loss in response to high-intensity interval training (HIIT) and moderate continuous training (MCT) in individuals with type 2 diabetes mellitus (T2DM). Moreover, the impact on health-related outcomes in those who fail t...
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| Published in: | Frontiers in physiology 2021-09, Vol.12, p.698971-698971 |
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| creator | Magalhães, João P. Hetherington-Rauth, Megan Júdice, Pedro B. Correia, Inês R. Rosa, Gil B. Henriques-Neto, Duarte Melo, Xavier Silva, Analiza M. Sardinha, Luís B. |
| description | Purpose
: Little is known about the interindividual variability in fat mass (FM) loss in response to high-intensity interval training (HIIT) and moderate continuous training (MCT) in individuals with type 2 diabetes mellitus (T2DM). Moreover, the impact on health-related outcomes in those who fail to reduce FM is still unclear. The aims of this investigation were (1) to assess if the individuals with T2DM who FM differed across MCT, HIIT, and control groups over a 1-year intervention and (2) to assess the changes on glycemic control and vascular function in the exercising patients who failed to lose FM.
Methods
: Adults with T2DM were randomized into a 1-year intervention involving a control group (
n
=22), MCT with resistance training (RT;
n
=21), and HIIT with RT (
n
=19). FM was assessed using dual-energy X-ray absorptiometry and a change in total body FM above the typical error was used to categorize FM responders. Glycemic control and vascular stiffness and structure were assessed. A chi-square test and generalized estimating equations were used to model the outcomes.
Results
: Both MCT (
n
=10) and HIIT (
n
=10) had a similar proportion of individuals who were categorized as high responders for FM, with the percent change in FM on average −5.0±9.6% for the MCT and −6.0±12.1% for the HIIT, which differed from the control group (0.2±7.6%) after a 1-year intervention (
p |
| doi_str_mv | 10.3389/fphys.2021.698971 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_8540fce6335d413792441d97727bcdf2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_8540fce6335d413792441d97727bcdf2</doaj_id><sourcerecordid>2579090319</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-ada299ad30431ed48382105c846fbfeba28681134a6a567628169ed92d678cfc3</originalsourceid><addsrcrecordid>eNpVks1uEzEUhUcIRKvSB2DnJZsE_8Vjs0BCoSmRipCq8LeyPPadxpVnHGxPRXhBXgunKYh6c698j79zZZ2meUnwnDGpXve77T7PKaZkLpRULXnSnBIh-Axz-u3pf_1Jc57zLa6HY4oxed6cMC4wwy07bX6vxwLJj87feTeZgL6Y5E3ngy975Ee0MgV9NDmja8i7OGZAJSKDyOw7mISuzeji4H-BQ8s4lhRDqO2mEgL66ssWvfd9DwnGgi5-QrK-vj8YjtkXD_lgsNnvANEqNB0UyG_QetgFb03x1Q3FEV2GvYXB278OqHrWLbOdQt1gNY32IH3RPOtNyHD-UM-az6uLzfLD7OrT5Xr57mpmOadlZpyhShnHMGcEHJdMUoIXVnLRdz10hkohCWHcCLMQraCSCAVOUSdaaXvLzpr1keuiudW75AeT9joar-8vYrrRJhVvA2i54Li3IBhbOE5YqyjnxKm2pW1nXU8r6-2RtZu6AZyt35RMeAR9PBn9Vt_EOy25JIrjCnj1AEjxxwS56MFnCyGYEeKUNV20CivMiKpScpTaFHNO0P-zIVgf8qTv86QPedLHPLE_KFvBWQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2579090319</pqid></control><display><type>article</type><title>Interindividual Variability in Fat Mass Response to a 1-Year Randomized Controlled Trial With Different Exercise Intensities in Type 2 Diabetes: Implications on Glycemic Control and Vascular Function</title><source>PubMed (Medline)</source><creator>Magalhães, João P. ; Hetherington-Rauth, Megan ; Júdice, Pedro B. ; Correia, Inês R. ; Rosa, Gil B. ; Henriques-Neto, Duarte ; Melo, Xavier ; Silva, Analiza M. ; Sardinha, Luís B.</creator><creatorcontrib>Magalhães, João P. ; Hetherington-Rauth, Megan ; Júdice, Pedro B. ; Correia, Inês R. ; Rosa, Gil B. ; Henriques-Neto, Duarte ; Melo, Xavier ; Silva, Analiza M. ; Sardinha, Luís B.</creatorcontrib><description>Purpose
: Little is known about the interindividual variability in fat mass (FM) loss in response to high-intensity interval training (HIIT) and moderate continuous training (MCT) in individuals with type 2 diabetes mellitus (T2DM). Moreover, the impact on health-related outcomes in those who fail to reduce FM is still unclear. The aims of this investigation were (1) to assess if the individuals with T2DM who FM differed across MCT, HIIT, and control groups over a 1-year intervention and (2) to assess the changes on glycemic control and vascular function in the exercising patients who failed to lose FM.
Methods
: Adults with T2DM were randomized into a 1-year intervention involving a control group (
n
=22), MCT with resistance training (RT;
n
=21), and HIIT with RT (
n
=19). FM was assessed using dual-energy X-ray absorptiometry and a change in total body FM above the typical error was used to categorize FM responders. Glycemic control and vascular stiffness and structure were assessed. A chi-square test and generalized estimating equations were used to model the outcomes.
Results
: Both MCT (
n
=10) and HIIT (
n
=10) had a similar proportion of individuals who were categorized as high responders for FM, with the percent change in FM on average −5.0±9.6% for the MCT and −6.0±12.1% for the HIIT, which differed from the control group (0.2±7.6%) after a 1-year intervention (
p
<0.05). A time-by-group interaction for carotid artery intima-media thickness (cIMT) (p for interaction=0.042) and lower-limb pulse wave velocity (LL PWV; p for interaction=0.010) between those categorized as low FM responders and the control group. However, an interaction was observed between the high responders for FM loss and controls for both brachial and carotid hemodynamic indices, as well as in cIMT, carotid distensibility coefficient, carotid beta index, and LL PWV (p for interactions <0.05). No interactions were found for glycaemic indices (p for interaction >0.05).
Conclusion
: Our results suggest that the number of FM responders did not differ between the MCT or HIIT, compared to the control, following a 1-year exercise intervention in individuals with T2DM. However, low responders to FM may still derive reductions in arterial stiffness and structure.
Clinical Trial Registration
: Comparing Moderate and High-intensity Interval Training Protocols on Biomarkers in Type 2 Diabetes Patients (D2FIT study) – number: NCT03144505 (
https://clinicaltrials.gov/ct2/show/NCT03144505
).</description><identifier>ISSN: 1664-042X</identifier><identifier>EISSN: 1664-042X</identifier><identifier>DOI: 10.3389/fphys.2021.698971</identifier><identifier>PMID: 34603073</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>arterial stiffness ; Carotid artery intima-media thickness ; exercise intervention ; high-intensity interval training ; moderate continuous training ; peak wave velocity ; Physiology</subject><ispartof>Frontiers in physiology, 2021-09, Vol.12, p.698971-698971</ispartof><rights>Copyright © 2021 Magalhães, Hetherington-Rauth, Júdice, Correia, Rosa, Henriques-Neto, Melo, Silva and Sardinha. 2021 Magalhães, Hetherington-Rauth, Júdice, Correia, Rosa, Henriques-Neto, Melo, Silva and Sardinha</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ada299ad30431ed48382105c846fbfeba28681134a6a567628169ed92d678cfc3</citedby><cites>FETCH-LOGICAL-c442t-ada299ad30431ed48382105c846fbfeba28681134a6a567628169ed92d678cfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481940/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481940/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Magalhães, João P.</creatorcontrib><creatorcontrib>Hetherington-Rauth, Megan</creatorcontrib><creatorcontrib>Júdice, Pedro B.</creatorcontrib><creatorcontrib>Correia, Inês R.</creatorcontrib><creatorcontrib>Rosa, Gil B.</creatorcontrib><creatorcontrib>Henriques-Neto, Duarte</creatorcontrib><creatorcontrib>Melo, Xavier</creatorcontrib><creatorcontrib>Silva, Analiza M.</creatorcontrib><creatorcontrib>Sardinha, Luís B.</creatorcontrib><title>Interindividual Variability in Fat Mass Response to a 1-Year Randomized Controlled Trial With Different Exercise Intensities in Type 2 Diabetes: Implications on Glycemic Control and Vascular Function</title><title>Frontiers in physiology</title><description>Purpose
: Little is known about the interindividual variability in fat mass (FM) loss in response to high-intensity interval training (HIIT) and moderate continuous training (MCT) in individuals with type 2 diabetes mellitus (T2DM). Moreover, the impact on health-related outcomes in those who fail to reduce FM is still unclear. The aims of this investigation were (1) to assess if the individuals with T2DM who FM differed across MCT, HIIT, and control groups over a 1-year intervention and (2) to assess the changes on glycemic control and vascular function in the exercising patients who failed to lose FM.
Methods
: Adults with T2DM were randomized into a 1-year intervention involving a control group (
n
=22), MCT with resistance training (RT;
n
=21), and HIIT with RT (
n
=19). FM was assessed using dual-energy X-ray absorptiometry and a change in total body FM above the typical error was used to categorize FM responders. Glycemic control and vascular stiffness and structure were assessed. A chi-square test and generalized estimating equations were used to model the outcomes.
Results
: Both MCT (
n
=10) and HIIT (
n
=10) had a similar proportion of individuals who were categorized as high responders for FM, with the percent change in FM on average −5.0±9.6% for the MCT and −6.0±12.1% for the HIIT, which differed from the control group (0.2±7.6%) after a 1-year intervention (
p
<0.05). A time-by-group interaction for carotid artery intima-media thickness (cIMT) (p for interaction=0.042) and lower-limb pulse wave velocity (LL PWV; p for interaction=0.010) between those categorized as low FM responders and the control group. However, an interaction was observed between the high responders for FM loss and controls for both brachial and carotid hemodynamic indices, as well as in cIMT, carotid distensibility coefficient, carotid beta index, and LL PWV (p for interactions <0.05). No interactions were found for glycaemic indices (p for interaction >0.05).
Conclusion
: Our results suggest that the number of FM responders did not differ between the MCT or HIIT, compared to the control, following a 1-year exercise intervention in individuals with T2DM. However, low responders to FM may still derive reductions in arterial stiffness and structure.
Clinical Trial Registration
: Comparing Moderate and High-intensity Interval Training Protocols on Biomarkers in Type 2 Diabetes Patients (D2FIT study) – number: NCT03144505 (
https://clinicaltrials.gov/ct2/show/NCT03144505
).</description><subject>arterial stiffness</subject><subject>Carotid artery intima-media thickness</subject><subject>exercise intervention</subject><subject>high-intensity interval training</subject><subject>moderate continuous training</subject><subject>peak wave velocity</subject><subject>Physiology</subject><issn>1664-042X</issn><issn>1664-042X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVks1uEzEUhUcIRKvSB2DnJZsE_8Vjs0BCoSmRipCq8LeyPPadxpVnHGxPRXhBXgunKYh6c698j79zZZ2meUnwnDGpXve77T7PKaZkLpRULXnSnBIh-Axz-u3pf_1Jc57zLa6HY4oxed6cMC4wwy07bX6vxwLJj87feTeZgL6Y5E3ngy975Ee0MgV9NDmja8i7OGZAJSKDyOw7mISuzeji4H-BQ8s4lhRDqO2mEgL66ssWvfd9DwnGgi5-QrK-vj8YjtkXD_lgsNnvANEqNB0UyG_QetgFb03x1Q3FEV2GvYXB278OqHrWLbOdQt1gNY32IH3RPOtNyHD-UM-az6uLzfLD7OrT5Xr57mpmOadlZpyhShnHMGcEHJdMUoIXVnLRdz10hkohCWHcCLMQraCSCAVOUSdaaXvLzpr1keuiudW75AeT9joar-8vYrrRJhVvA2i54Li3IBhbOE5YqyjnxKm2pW1nXU8r6-2RtZu6AZyt35RMeAR9PBn9Vt_EOy25JIrjCnj1AEjxxwS56MFnCyGYEeKUNV20CivMiKpScpTaFHNO0P-zIVgf8qTv86QPedLHPLE_KFvBWQ</recordid><startdate>20210916</startdate><enddate>20210916</enddate><creator>Magalhães, João P.</creator><creator>Hetherington-Rauth, Megan</creator><creator>Júdice, Pedro B.</creator><creator>Correia, Inês R.</creator><creator>Rosa, Gil B.</creator><creator>Henriques-Neto, Duarte</creator><creator>Melo, Xavier</creator><creator>Silva, Analiza M.</creator><creator>Sardinha, Luís B.</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210916</creationdate><title>Interindividual Variability in Fat Mass Response to a 1-Year Randomized Controlled Trial With Different Exercise Intensities in Type 2 Diabetes: Implications on Glycemic Control and Vascular Function</title><author>Magalhães, João P. ; Hetherington-Rauth, Megan ; Júdice, Pedro B. ; Correia, Inês R. ; Rosa, Gil B. ; Henriques-Neto, Duarte ; Melo, Xavier ; Silva, Analiza M. ; Sardinha, Luís B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ada299ad30431ed48382105c846fbfeba28681134a6a567628169ed92d678cfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>arterial stiffness</topic><topic>Carotid artery intima-media thickness</topic><topic>exercise intervention</topic><topic>high-intensity interval training</topic><topic>moderate continuous training</topic><topic>peak wave velocity</topic><topic>Physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magalhães, João P.</creatorcontrib><creatorcontrib>Hetherington-Rauth, Megan</creatorcontrib><creatorcontrib>Júdice, Pedro B.</creatorcontrib><creatorcontrib>Correia, Inês R.</creatorcontrib><creatorcontrib>Rosa, Gil B.</creatorcontrib><creatorcontrib>Henriques-Neto, Duarte</creatorcontrib><creatorcontrib>Melo, Xavier</creatorcontrib><creatorcontrib>Silva, Analiza M.</creatorcontrib><creatorcontrib>Sardinha, Luís B.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magalhães, João P.</au><au>Hetherington-Rauth, Megan</au><au>Júdice, Pedro B.</au><au>Correia, Inês R.</au><au>Rosa, Gil B.</au><au>Henriques-Neto, Duarte</au><au>Melo, Xavier</au><au>Silva, Analiza M.</au><au>Sardinha, Luís B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interindividual Variability in Fat Mass Response to a 1-Year Randomized Controlled Trial With Different Exercise Intensities in Type 2 Diabetes: Implications on Glycemic Control and Vascular Function</atitle><jtitle>Frontiers in physiology</jtitle><date>2021-09-16</date><risdate>2021</risdate><volume>12</volume><spage>698971</spage><epage>698971</epage><pages>698971-698971</pages><issn>1664-042X</issn><eissn>1664-042X</eissn><abstract>Purpose
: Little is known about the interindividual variability in fat mass (FM) loss in response to high-intensity interval training (HIIT) and moderate continuous training (MCT) in individuals with type 2 diabetes mellitus (T2DM). Moreover, the impact on health-related outcomes in those who fail to reduce FM is still unclear. The aims of this investigation were (1) to assess if the individuals with T2DM who FM differed across MCT, HIIT, and control groups over a 1-year intervention and (2) to assess the changes on glycemic control and vascular function in the exercising patients who failed to lose FM.
Methods
: Adults with T2DM were randomized into a 1-year intervention involving a control group (
n
=22), MCT with resistance training (RT;
n
=21), and HIIT with RT (
n
=19). FM was assessed using dual-energy X-ray absorptiometry and a change in total body FM above the typical error was used to categorize FM responders. Glycemic control and vascular stiffness and structure were assessed. A chi-square test and generalized estimating equations were used to model the outcomes.
Results
: Both MCT (
n
=10) and HIIT (
n
=10) had a similar proportion of individuals who were categorized as high responders for FM, with the percent change in FM on average −5.0±9.6% for the MCT and −6.0±12.1% for the HIIT, which differed from the control group (0.2±7.6%) after a 1-year intervention (
p
<0.05). A time-by-group interaction for carotid artery intima-media thickness (cIMT) (p for interaction=0.042) and lower-limb pulse wave velocity (LL PWV; p for interaction=0.010) between those categorized as low FM responders and the control group. However, an interaction was observed between the high responders for FM loss and controls for both brachial and carotid hemodynamic indices, as well as in cIMT, carotid distensibility coefficient, carotid beta index, and LL PWV (p for interactions <0.05). No interactions were found for glycaemic indices (p for interaction >0.05).
Conclusion
: Our results suggest that the number of FM responders did not differ between the MCT or HIIT, compared to the control, following a 1-year exercise intervention in individuals with T2DM. However, low responders to FM may still derive reductions in arterial stiffness and structure.
Clinical Trial Registration
: Comparing Moderate and High-intensity Interval Training Protocols on Biomarkers in Type 2 Diabetes Patients (D2FIT study) – number: NCT03144505 (
https://clinicaltrials.gov/ct2/show/NCT03144505
).</abstract><pub>Frontiers Media S.A</pub><pmid>34603073</pmid><doi>10.3389/fphys.2021.698971</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_8540fce6335d413792441d97727bcdf2 |
| source | PubMed (Medline) |
| subjects | arterial stiffness Carotid artery intima-media thickness exercise intervention high-intensity interval training moderate continuous training peak wave velocity Physiology |
| title | Interindividual Variability in Fat Mass Response to a 1-Year Randomized Controlled Trial With Different Exercise Intensities in Type 2 Diabetes: Implications on Glycemic Control and Vascular Function |
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