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Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization

The skin, known as the largest organ of the body, is essential for maintaining physiological balance and acts as a barrier against the external environment. When skin becomes damaged and wounds appear on the skin's surface, a complex healing process, involving multiple types of cells and microe...

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Bibliographic Details
Published in:Gels 2024-11, Vol.10 (11), p.729
Main Authors: Coman, Alina Elena, Marin, Maria Minodora, Roșca, Ana Maria, Albu Kaya, Madalina Georgiana, Constantinescu, Rodica Roxana, Titorencu, Irina
Format: Article
Language:English
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Summary:The skin, known as the largest organ of the body, is essential for maintaining physiological balance and acts as a barrier against the external environment. When skin becomes damaged and wounds appear on the skin's surface, a complex healing process, involving multiple types of cells and microenvironments, take place. Selecting a suitable dressing for a wound is crucial for accelerating healing, reducing treatment costs, and improving the patient's overall health. Starting from natural resources such as perch skin ( ), this article aims to develop biocompatible materials for regenerative medicine from collagen in the form of gels/gelatines. The extracted gels were physical/chemical and structurally analyzed. In order to obtain collagen scaffolds for wound healing, the extracted collagen gels from perch skin were further freeze-dried. The ability of these scaffolds is essential for controlling moisture levels during wound healing; therefore, it was necessary to investigate the samples' ability to absorb water. The assessed collagen-based scaffolds were microbiologically tested, and their biocompatibility was investigated by incubating human adult dermal fibroblasts. The outcomes reveal an innovative path for the production of biomaterials used in wound healing, starting from collagen derived from marine sources.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels10110729