Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy

While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the...

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Bibliographic Details
Published in:Communications biology 2020-12, Vol.3 (1), p.742-742, Article 742
Main Authors: Miyanaga, Noriaki, Takagi, Hideaki, Uto, Tomofumi, Fukaya, Tomohiro, Nasu, Junta, Fukui, Takehito, Nishikawa, Yotaro, Sparwasser, Tim, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Nakamura, Takeshi, Tono, Tetsuya, Sato, Katsuaki
Format: Article
Language:English
Subjects:
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Allergens
Allergies
Antigens
Biology
Biomedical and Life Sciences
CD11b antigen
CD4 antigen
Cell migration
Dendritic cells
Foxp3 protein
Immunological tolerance
Immunoregulation
Immunotherapy
Life Sciences
Lymph nodes
Lymphatic system
Lymphocytes T
Mucosa
Oral administration
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Summary:While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4 + Foxp3 + regulatory T (T reg ) cells abrogates the protective effect of SLIT against allergic disorders. Furthermore, sublingual antigenic application primarily induces antigen-specific CD4 + Foxp3 + T reg cells in draining ManLNs, in which it is severely impaired in the absence of cDCs. In ManLNs, migratory CD11b + cDCs are superior to other conventional dendritic cell subsets for the generation of antigen-specific CD4 + Foxp3 + T reg cells, which is reflected by their dominancy in the tolerogenic features to favor this program. Thus, ManLNs are privileged sites in triggering mucosal tolerance mediating protect effect of SLIT on allergic disorders that requires a tolerogenesis of migratory CD11b + conventional dendritic cells. Noriaki Miyanaga and Hideaki Takagi et al. identify an essential role for migratory dendritic cells in mediating immunotherapy treatment against allergies in mice. They show that submandibular lymph node dendritic cells induce regulatory T cells, and their absence abrogates the effectiveness of immunotherapy treatment.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-020-01466-3