Boswellia serrata Extract as an Antibiofilm Agent against Candida spp

The use of antibiotics or antifungals to control infections caused by pathogenic microorganisms is currently insufficiently effective because of their emerging resistance. Thanks to the ability of microorganisms to form a biofilm and thus increase their resistance to administered drugs even more, mo...

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Bibliographic Details
Published in:Microorganisms (Basel) 2022-01, Vol.10 (1), p.171
Main Authors: Jaroš, Petr, Vrublevskaya, Maria, Lokočová, Kristýna, Michailidu, Jana, Kolouchová, Irena, Demnerová, Kateřina
Format: Article
Language:English
Subjects:
Acids
Alzheimer's disease
Antibiotics
Antifungal activity
Antimicrobial agents
biofilm
Biofilms
Biological activity
Biosynthesis
Boswellia serrata
boswellic acid
Candida
Candida albicans
Candida krusei
Candida parapsilosis
Drug resistance
Essential oils
Ethanol
fluconazole
Fungicides
Glucose
Inflammatory bowel disease
Metabolism
Microorganisms
Nosocomial infection
Pathogens
Physiology
Plant extracts
Species
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Summary:The use of antibiotics or antifungals to control infections caused by pathogenic microorganisms is currently insufficiently effective because of their emerging resistance. Thanks to the ability of microorganisms to form a biofilm and thus increase their resistance to administered drugs even more, modern medicine faces the task of finding novel substances to combat infections caused by them. In this regard, the effects of essential oils or plant extracts are often studied. Among the relatively neglected plants is Boswellia serrata, which has a high content of biologically active boswellic acids. In this study, we focused on one of the most common nosocomial infections, which are caused by Candida species. The most common representative is C. albicans, although the number of infections caused by non-albicans species has recently been increasing. We focused on the antifungal activity of Boswellia serrata extract Bioswellix against planktonic and adhering cells of Candida albicans, Candida parapsilosis and Candida krusei. The antifungal activity against adhering cells was further explored by determining the metabolic activity of cells (MTT) and determining the total amount of biofilm using crystal violet. Boswellic acid-containing plant extract was shown to suppress the growth of a suspension population of all tested Candida species. Boswellia serrata extract Bioswellix was most effective in inhibiting C. albicans biofilm formation.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10010171