Serum α-Klotho level, lung function, airflow obstruction and inflammatory markers in US adults

α-Klotho is a pleiotropic protein that may have anti-oxidative and anti-inflammatory properties in the lung, but its role in airflow obstruction or lung function is largely unknown. This was a cross-sectional study of 6046 adults aged 40-79 years in the US National Health and Nutrition Examination S...

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Published in:ERJ open research 2023-11, Vol.9 (6), p.471
Main Authors: Han, Yueh-Ying, Celedón, Juan C, Forno, Erick
Format: Article
Language:English
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Summary:α-Klotho is a pleiotropic protein that may have anti-oxidative and anti-inflammatory properties in the lung, but its role in airflow obstruction or lung function is largely unknown. This was a cross-sectional study of 6046 adults aged 40-79 years in the US National Health and Nutrition Examination Survey (NHANES) 2007-2012. We used multivariable logistic or linear regression to examine the relation between serum α-Klotho level and airflow obstruction, defined as forced expiratory volume in 1 s (FEV )
ISSN:2312-0541
2312-0541
DOI:10.1183/23120541.00471-2023