Photostability and Photostabilization of Drugs and Drug Products

Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the...

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Bibliographic Details
Published in:International journal of photoenergy 2016-01, Vol.2016 (2016), p.1-19
Main Authors: Sheraz, Muhammad Ali, Anwar, Zubair, Ahmed, Sofia, Ahmad, Iqbal, Sikorski, Marek
Format: Article
Language:English
Subjects:
Acids
Aqueous solutions
Catalysis
Drugs
Effectiveness
Guidelines
Integrals
Light
Liquids
Oxidation
Packaging
Pharmaceutical industry
Pharmaceutical sciences
Photochemistry
Photodegradation
Product safety
Solvents
Studies
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Summary:Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the concept of photostability and related aspects and the literature available in the field. It highlights the role of the photochemistry in the photostability studies, describes the functional groups important for the photoreactivity of drugs, explains photophysical processes, and deals with the kinetics of photochemical reactions. The various modes of photodegradation of drugs with examples of selected compounds are presented. The biological consequences of the effect of light on the drug degradation are described. The photostability testing of drugs and drug products and the requirements under ICH guideline are discussed. Some information on the packaging requirements for the formulated products is provided. The various methods used for the photostabilization of solid and liquid dosage forms are also discussed.
ISSN:1110-662X
1687-529X
DOI:10.1155/2016/8135608