Predictors of hospital-acquired adverse drug reactions: a cohort of Ugandan older adults

Globally, it is estimated that the number of older adults will become 2 billion by 2050. The identification of the predictors of adverse drug reaction (ADR) in hospitalized older patients is crucial to the development of prediction tools and preventive strategies to mitigate the burden of ADRs. This...

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Bibliographic Details
Published in:BMC geriatrics 2022-04, Vol.22 (1), p.359-11, Article 359
Main Authors: Yadesa, Tadele Mekuriya, Kitutu, Freddy Eric, Tamukong, Robert, Alele, Paul E
Format: Article
Language:English
Subjects:
Adverse and side effects
Adverse drug reaction
Age
Aged
Aged patients
Allergies
Cancer therapies
Care and treatment
Cohort Studies
Congestive heart failure
Coronary artery disease
Developing countries
Disease prevention
Drug use
Drug-Related Side Effects and Adverse Reactions - diagnosis
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drugs
Gender
Geriatrics
Gynecology
Heart diseases
Heart failure
Herbal medicine
Hospital-acquired
Hospitalization
Hospitals
Humans
Kidney diseases
Laboratories
Language
LDCs
Liver diseases
Medicine
Occurrence
Older adults
Older people
Oncology
Patients
Population
Predictors
Prospective Studies
Risk Factors
Sample size
Surgery
Systematic review
Uganda
Uganda - epidemiology
Variables
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Summary:Globally, it is estimated that the number of older adults will become 2 billion by 2050. The identification of the predictors of adverse drug reaction (ADR) in hospitalized older patients is crucial to the development of prediction tools and preventive strategies to mitigate the burden of ADRs. This study aimed to determine the predictors of hospital-acquired ADR occurrence among hospitalized older adults in a low-income country. We conducted a prospective cohort of older adults admitted to medical, oncology, and surgery wards at Mbarara Regional Referral Hospital (MRRH) for a consecutive 6 months where each patient was followed up daily from admission to discharge. We used Edwards and Aronson's definition of ADR and the Naranjo ADR Causality Scale. We employed Beer's criteria and Lexicomp to determine potentially inappropriate medications, and drug interactions, respectively. We conducted univariate and multivariable logistic regression using Statistical Package for the Social Science (SPSS) Version 23.0. Out of 523 participants with median (Inter Quartile Range) age of 67 (62-76) years, 256 (48.9%) experienced at least one ADR. Independent predictors of occurrence of hospital acquired ADRs included age of 60-75 (Adjusted odds ratio (AOR) = 1.97, 95% C.I: 1.14-3.41; p value = 0.015) compared to > 75 years, previous ADR in 1 year (AOR = 2.43, 95% C.I: 1.42-4.17; p value = 0.001), potentially inappropriate medication (AOR = 4.56, 95% C.I: 2.70-7.70; p value
ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-022-03003-9