A Palladium-Catalyzed 4CzIPN-Mediated Decarboxylative Acylation Reaction of O-Methyl Ketoximes with α-Keto Acids under Visible Light

This work presents a palladium-catalyzed oxime ether-directed ortho-selective benzoylation using benzoylformic acid as the acyl source with a palladium catalyst and 4CzIPN as the co-catalyst under light. Various non-symmetric benzophenone derivatives were obtained in moderate to good yields. A preli...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-03, Vol.27 (6), p.1980
Main Authors: Wang, Cheng, Yang, Shan, Huang, Zhibin, Zhao, Yingsheng
Format: Article
Language:English
Subjects:
Acids
Acylation
Benzophenone
Benzoylation
Catalysis
Catalysts
C–H activation
decarboxylation
Fluorine
Free radicals
Investigations
Keto Acids
Light
Oximes
Palladium
palladium catalysis
visible light
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Summary:This work presents a palladium-catalyzed oxime ether-directed ortho-selective benzoylation using benzoylformic acid as the acyl source with a palladium catalyst and 4CzIPN as the co-catalyst under light. Various non-symmetric benzophenone derivatives were obtained in moderate to good yields. A preliminary mechanism study revealed that the reaction proceeds through a free radical pathway.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27061980