Correlation between C-reactive Protein with Malondialdehyde in Systemic Lupus Erythematosus Patients

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SL...

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Bibliographic Details
Published in:International journal of rheumatology 2020, Vol.2020 (2020), p.1-5
Main Authors: Atik, Nur, Hamijoyo, Laniyati, Putri Pratiwi, S.
Format: Article
Language:English
Subjects:
Analysis
C-reactive protein
Disease
Employees
Enzyme-linked immunosorbent assay
Free radicals
Inflammation
Lupus
Medical research
Medicine, Experimental
Oxidative stress
Patients
Proteins
Studies
Systemic lupus erythematosus
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Summary:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus registry data, and MDA levels were analyzed from a bioarchive patient’s serum. We collected the patients’ data who had CRP level from Hasan Sadikin lupus registry and analysed MDA levels from the serum sample. MDA levels were analyzed using an ELISA method. The data obtained were analyzed using the Pearson correlation and Eta correlation test. The study involved 78 data patients as subjects. It was found that the median of CRP and MDA was 0.85 mg/l and 153.10 ng/ml, respectively. These results indicate that the CRP levels in SLE patients are still within normal limits. Statistical analysis showed no correlation between CRP and MDA level (r=0.2, P>0.05). Additionally, the correlation between CRP and MDA with organ involvement, such as lupus nephritis (LN), lupus cutaneous (LC), and lupus musculoskeletal (LM), showed no correlation (Fh
ISSN:1687-9260
1687-9279
DOI:10.1155/2020/8078412