Automatic 3D dense phenotyping provides reliable and accurate shape quantification of the human mandible

Automatic craniomaxillofacial (CMF) three dimensional (3D) dense phenotyping promises quantification of the complete CMF shape compared to the limiting use of sparse landmarks in classical phenotyping. This study assesses the accuracy and reliability of this new approach on the human mandible. Class...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.8532-8532, Article 8532
Main Authors: Verhelst, Pieter-Jan, Matthews, H., Verstraete, L., Van der Cruyssen, F., Mulier, D., Croonenborghs, T. M., Da Costa, O., Smeets, M., Fieuws, S., Shaheen, E., Jacobs, R., Claes, P., Politis, C., Peeters, H.
Format: Article
Language:English
Subjects:
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Accuracy
Correlation coefficient
Hospitals
Humanities and Social Sciences
Mandible
Maxillofacial surgery
Medicin och hälsovetenskap
multidisciplinary
Phenotyping
Registration
Science
Science (multidisciplinary)
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Summary:Automatic craniomaxillofacial (CMF) three dimensional (3D) dense phenotyping promises quantification of the complete CMF shape compared to the limiting use of sparse landmarks in classical phenotyping. This study assesses the accuracy and reliability of this new approach on the human mandible. Classic and automatic phenotyping techniques were applied on 30 unaltered and 20 operated human mandibles. Seven observers indicated 26 anatomical landmarks on each mandible three times. All mandibles were subjected to three rounds of automatic phenotyping using Meshmonk. The toolbox performed non-rigid surface registration of a template mandibular mesh consisting of 17,415 quasi landmarks on each target mandible and the quasi landmarks corresponding to the 26 anatomical locations of interest were identified. Repeated-measures reliability was assessed using root mean square (RMS) distances of repeated landmark indications to their centroid. Automatic phenotyping showed very low RMS distances confirming excellent repeated-measures reliability. The average Euclidean distance between manual and corresponding automatic landmarks was 1.40 mm for the unaltered and 1.76 mm for the operated sample. Centroid sizes from the automatic and manual shape configurations were highly similar with intraclass correlation coefficients (ICC) of > 0.99. Reproducibility coefficients for centroid size were 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-88095-w